| Clinical characteristics of early-onset type 2 diabetes mellitus patients with different body mass index level |
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| Citation of this paper:CAO Jing-zhu1△, WANG Yuan-chen2△, HONG Hui-lan3, HUANG Qin1*.Clinical characteristics of early-onset type 2 diabetes mellitus patients with different body mass index level[J].Chinese Journal of Clinical Medicine,2019,26(1):14-18 |
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| Author Name | Affiliation | | CAO Jing-zhu1△, WANG Yuan-chen2△, HONG Hui-lan3, HUANG Qin1* | 1. Department of Endocrinology, Changhai Hospital, Navy Military Medical University, Shanghai 200433, China
2. School of Basic Medicine, Navy Military Medical University, Shanghai 200433, China
3. Department of Special Needs Clinic, Changhai Hospital, Navy Military Medical University, Shanghai 200433, China |
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| Abstract:Objective：To compare the clinical characteristics of early-onset type 2 diabetes mellitus (T2DM) patients with different body mass index (BMI). Methods：Totally 287 cases of initial-diagnosed T2DM patients (age≤35 years old) were divided into overweight group (BMI≥24 kg/m2, n=190) and normal-weight group (BMI＜24 kg/m2, n=97). The general information and biochemical indexes were compared between the two groups. Results：Compared with the normal-weight group, the overweight group had significantly higher proportion of male patients, significantly higher prevalence of hypertension and non-alcoholic fatty liver disease (NAFLD, P<0.01). Compared with normal-weight group, the patients in overweight group had significantly higher levels of fasting glucose (FPG), fasting serum insulin (FINS), postprandial 2-hour insulin (2 h INS), fasting C-peptide (FC-P), postprandial 2-hour C-peptide (2 h C-P), insulin resistance index (HOMA-IR), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (γ-GT), total cholesterol (TC), triglyceride (TG), serum creatinine (SCr), and uric acid (UA, P<0.01). While the levels of glycated hemoglobin (HbA1c), glycated albumin (GA), high density lipoprotein cholesterol (HDL-C) were significantly lower than those in the normal-weight group (P<0.05). Conclusions：Early-onset and overweight T2DM patients have a higher prevalence of hypertension and NAFLD, with more serious liver and renal dysfunction, HOMA-IR, and metabolism disorders. |
| keywords:early-onset type 2 diabetes mellitus body mass index clinical characteristics |
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