| The value of thyroid hormone combined with diffusion-weighted imaging in the evaluation of relapsing-remitting multiple sclerosis |
| Click here to download the full text |
| Citation of this paper:YU Wei-bin1, WEI Wei2*, ZHOU Ya-jun3, WEI Xiao-er1.The value of thyroid hormone combined with diffusion-weighted imaging in the evaluation of relapsing-remitting multiple sclerosis[J].Chinese Journal of Clinical Medicine,2018,25(5):773-777 |
| Hits: 1597 |
| Download times: 941 |
| Author Name | Affiliation | | YU Wei-bin1, WEI Wei2*, ZHOU Ya-jun3, WEI Xiao-er1 | 1.Institute of Diagnostic and Interventional Radiology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China
2.Department of Laboratory, Shanghai Eighth People’s Hospital, Shanghai 200235, China
3.Department of Neurology, the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China |
|
| Abstract:Objective：To explore the value of thyroid hormone combined with diffusion-weighted imaging in the evaluation of relapsing-remitting MS (RRMS).
Methods：The clinical data of relapsing-remitting MS were retrospectively analyzed. The relapsing-remitting MS patients were divided into acute attack group and remission group according to the clinical courses. And health examination cases were enrolled as the control group. The difference in TSH, fT3, T3, fT4, T4, and ATA among the three groups was analyzed. The differences in the total MS lesions and DWI hyperintensity lesions between acute attack group and remission group were also analyzed. The relationship between thyroid hormone and the burden of DWI hyperintensity lesion was analyzed.
Results：A total of 51 RRMS patients with 757 MS lesions were found in the final analysis. No difference was found in age, sex, and the total MS lesions among the three groups. The clinical course time in the acute attack group was shorter than that in the remission group (P=0.003). The levels of fT3, T3, and TSH in the acute attack group were all lower than those in the remission group and control group (P<0.05). The level of fT4 in the acute attack group were all lower than that in the control group (P=0.015) and had a decreasing trend compared with the remission group (P=0.072). The level of TSH in the remission group had a decreasing trend compared with the control group (P=0.091). The positive rate of ATA in the acute attack group was higher than that in the control group (P=0.044). The positive rate of ATA in the remission group had an increasing trend compared with the control group (P=0.09). There were more patients with DWI hyperintensity lesions in the acute attack group than those in the remission group (P=0.002). The burden of DWI hyperintensity lesion in the acute attack group was more serious than that in the remission group (P=0.001). The burden of DWI hyperintensity lesion had a trend to negatively correlate with the level of fT3 (r=-0.332, P=0.097).
Conclusions：Thyroid hormone and DWI is helpful to evaluate the clinical course of relapsing remission MS. |
| keywords:multiple sclerosis relapse remission diffusion-weighted imaging thyroid hormone |
| HTML View Full Text View/Add Comment Download reader |
|
|
|