Expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma |
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Citation of this paper:PENG Rui1,HUANG Xiao-yong2,CAI Jia-bin2,KE Ai-wu2,SHI Guo-ming2,BAI Dou-sheng1,3*.Expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma[J].Chinese Journal of Clinical Medicine,2018,25(4):573-577 |
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Author Name | Affiliation | PENG Rui1,HUANG Xiao-yong2,CAI Jia-bin2,KE Ai-wu2,SHI Guo-ming2,BAI Dou-sheng1,3* | 1.The Second Xiangya Hospital, Central South University, Changsha 410000, Hunan, China2.Institute of Liver Cancer, ZhongshanHospital, Fudan University, Shanghai 20032, China3.The Subei People’s Hospital, Yangzhou University, Yangzhou 225001, Jiangsu, China |
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Abstract:Objective:To investigate the expression and clinical significance of TRIM44 and MMP9 in intrahepatic cholangiocarcinoma (ICC). Methods:The expression of TRIM44 and MMP9 in 87 ICC patients were analyzed by immunohistochemistry. And the clinical significance of TRIM44 and MMP9 were investigated by Kaplan-Meier and Cox regression models. Results:The expressions of TRIM44 and MMP9 were upregulated in tumor tissues of ICC. TRIM44 was positively associated with MMP9 expression in ICC (P<0.001). TRIM44 expression was significantly correlated with the lymph node metastasis (P=0.014), and MMP9 was significantly correlated with the tumor size, AFP concentration, and lymph node metastasis (P<0.05). Simultaneous overexpression of TRIM44 and MMP9 suggested poor prognosis of ICC patients. Conclusions:TRIM44 and MMP9 are overexpressed in ICC and are closely related to each other. The high expressiones of both suggest poor prognosis of ICC patients. |
keywords:TRIM44 MMP9 ICC prognosis |
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