| Effect-site concentration of propofol in cesarean section under general anesthesia using Schnider model |
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| Citation of this paper:.Effect-site concentration of propofol in cesarean section under general anesthesia using Schnider model[J].Chinese Journal of Clinical Medicine,2018,25(6):910-914 |
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| Abstract:Objective：To determine the target propofol effect-site concentration (ECe) that is needed for adequate depth of anesthesia in cesarean section under general anesthesia using the Schnider model. Methods：Seventy-two ASA Ⅰ-Ⅱparturients undergoing elective cesarean section under general anesthesia were selected. Parturients were allocated into six groups (twelve patients in each) and received propofol withdifferent ECe（4.0、4.5、5.0、5.5、6.0、6.5 μg/mL）. Propofol target-controlled infusion was performed using the Schnider model. After loss of consciousness,tracheal intubation was performed 1 minute later when the bispectral index (BIS) value was <60 and target propofol ECe had been reached. Probit regression analysis was performed to calculate the ECe50 and ECe95 of propofol for the induction of general anesthesia in parturients. Mean arterial pressure (MAP), heart rate (HR), BIS, Apgar score, neonatal umbilical artery blood gas, and delivery time were obtained and recorded. Results：The general characteristics of Parturients among 6 groups were not significantly different. The calculated propofol ECe50 and the ECe95 were 5.14 μg/mL (95%CI 4.90-5.38) and 6.07 μg/mL (95%CI 5.72-6.96) respectively for the induction of general anesthesia in parturients.There were no significantly differences in MAP, HR, Apgar score, neonatal umbilical artery blood gas, and delivery time among different 6 groups. Conclusions：The ECe50 and ECe95 were 5.14 μg/mL and 6.07 μg/mL respectively for the induction of general anesthesia in parturients undergoing elective cesarean section when using the Schnider model. |
| keywords:parturients propofol effect-site concentration general anesthesia cesarean section |
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