| Relationship between serum chemerin and interleukin-6 in patients with type 2 diabetes combined with metabolic syndrome |
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| Citation of this paper:MA Jun-hua, LU Jian-can, WANG Xing, ZHU Hong-ling, GU Ming-jun*.Relationship between serum chemerin and interleukin-6 in patients with type 2 diabetes combined with metabolic syndrome[J].Chinese Journal of Clinical Medicine,2018,25(5):748-752 |
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| Abstract:Objective：To detect the levels of serum chemerin in type 2 diabetic patients combined with metabolic syndrome (MS) and investigate the relationship between chemerin and interleukin-6 (IL-6).
Methods：The clinical data of 108 newly diagnosed type 2 diabetic patients were analyzed, among which, 58 patients were assigned to the MS group and 50 patients were assigned to the non MS group. Forty healthy patients during the same period were selected as the control group. The levels of serum chemerin, IL-6, fasting blood-glucose (FBG), glycosylated hemoglobin A1c (HbAlc), fasting insulin (FINS), and serum lipid were detected in three groups. Homeostasis model assessment of insulin resistance (HOMA-IR), body mass index (BMI) and waist-to-hip ratio (WHR) were calculated.
Results：Serum chemerin level was significantly higher in MS group than that in non MS group and control group (［77.2±9.2］ ng/mL vs［65.3±6.5］ ng/mL, ［77.2±9.2］ ng/mL vs［56.5±6.2］ ng/mL, P<0.05 and P<0.01, respectively). Compared with non-MS group and control group, the serum IL-6 level was significantly increased in MS group［48.8±6.4］ pg/mL vs［41.4±7.2］ pg/mL,［48.8±6.4］ pg/mL vs［32.7±4.9］pg/mL, P<0.01, respectively). Pearson correlation analysis showed that serum chemerin level was positively correlated with diastolic blood pressure, BMI, waist circumference, WHR, HOMA-IR, triglyceride (TG), and IL-6 (all P<0.05), and was negatively correlated with high-density lipoprotein cholesterol (HDL-C, P<0.01).
Conclusions：Serum chemerin level is increased in type 2 diabetic patients with MS, and the level of serum chemerin is positively correlated with IL-6. |
| keywords:type 2 diabetes mellitus metabolic syndrome chemerin interleukin-6 |
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