| Expression of YAP and FOXP1 mRNA in hepatocellular carcinoma and its influence on prognosis of patients with hepatocellular carcinoma |
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| Citation of this paper:CHEN Yuan1,ZHOU Yuan1,YIN Bi-hui2,LI Huai-liang2,HOU Wei-xiao2,ZHOU Yi-long1,SHAO Bing-feng1,ZHANG Su-qing1, XU Ai-bing1,ZHANG Yi-xin1*.Expression of YAP and FOXP1 mRNA in hepatocellular carcinoma and its influence on prognosis of patients with hepatocellular carcinoma[J].Chinese Journal of Clinical Medicine,2018,25(4):549-554 |
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| Author Name | Affiliation | | CHEN Yuan1,ZHOU Yuan1,YIN Bi-hui2,LI Huai-liang2,HOU Wei-xiao2,ZHOU Yi-long1,SHAO Bing-feng1,ZHANG Su-qing1, XU Ai-bing1,ZHANG Yi-xin1* | 1.Department of Surgery, Nantong Tumour Hospital, Nantong University, Nantong 226300, Jiangsu, China2.Department of Clinical Medicine, Graduate School, Nantong University School of Medicine, Nantong 226019, Jiangsu, China |
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| Abstract:Objective：To investigate the expression of Yes-associated protein (YAP) and Forkhead-box P1 (FOXP1) mRNA in hepatocellular carcinoma (HCC) and its influence on patients’ disease-free survival (DFS). Methods：Real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the mRNA expression of YAP, FOXP1 mRNA in paraffin embedded tissues of 114 HCC patients. Regression analysis was performed to estimate the effect of YAP and FOXP1 mRNA expression levels on the DFS time of HCC patients. Results：The mRNA expression levels of YAP and FOXP1 were significantly associated with tumor diameter, TNM stage, and AFP （P<0.05）. The expression level of YAP was directly correlated with that of FOXP1 (r=0.76, P<0.000 1). A univariate analysis showed that tumor differentiation, TNM stage, gross classification, α fetoprotein, HBV infection, YAP and FOXP1 expression were predictors of DFS in HCC patients. Furthermore, multivariate Cox proportional hazards regression analysis indicated that HBV infection and YAP/FOXP1 co-expression were independent prognostic factors for HCC （P<0.05）. Conclusions：High expression of FOXP1 and YAP mRNA in HCC tissue might affect the DFS prognosis of patients with HCC. |
| keywords:Yes associated protein Forkhead-box P1 hepatocellular carcinoma |
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