Relationship between free fatty acids and preeclampsia and gestational diabetes mellitus |
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Citation of this paper:ZHANG Rui-qing,XU Xian-ming,ZHANG Jia-rong*.Relationship between free fatty acids and preeclampsia and gestational diabetes mellitus[J].Chinese Journal of Clinical Medicine,2018,25(5):720-723 |
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Abstract:Objective:To investigate the effect of free fatty acid (FFA) on the incidence of preeclampsia and/or gestational diabetes mellitus (GDM) during late pregnancy.
Methods:A total of 417 pregnant women with preeclampsia and/or GDM were selected as the observation group, and another 2 018 normal pregnant women as the control group. The levels of serum lipids including total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and free fatty acid (FFA) were measured and compared between the two groups. The association between lipid metabolism and pregnancy complications were analyzed by logistic regression models.
Results:After adjusting for confounding factors, including pre-pregnancy body mass index (BMI), maternal age and gestational age at blood sampling, FFA concentrations measured during late pregnancy were associated with a significantly increased risk of preeclampsia, GDM and composite of preeclampsia and GDM(P<0.01). Furthermore, elevated maternal TG levels increased the risk of preeclampsia (P<0.001).
Conclusions:FFA levels during late pregnancy show strong relationships with the incidence of preeclampsia or GDM. |
keywords:free fatty acids triglyceride gestational diabetes mellitus preeclampsia |
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