| Abstract:Sphingosine-1-phosphate (S1P), a sphingomyelin metabolite with various biological activities, is involved in cell growth, apoptosis, regulation of immune and coagulation systems by binding to G-protein-coupled receptors (S1PRs) on the cell membrane surface. Sepsis is a life threating condition caused by infection induced immune response disorder, often leads to multiple organ dysfunction syndrome or multiple organ failure. The organ failure caused by sepsis is mainly related to the pathophysiological changes of endothelial cells and immune cells in the inflammatory environment, including increased vascular permeability, thrombosis, inflammation, and dysregulation of immune system. S1P might be involved in the regulation of various pathophysiological processes of sepsis and is expected to be an important marker for predicting the severity of sepsis and a potential target for the treatment of sepsis. This reviewsummarizes the experimental and clinical studies on S1P signal pathway in the development of sepsis, aiming to provide an insight into further investigation. |