Correlation between semi-quantitative index in breast specific gamma imaging and clinical features in patients with breast cancer |
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Citation of this paper:.Correlation between semi-quantitative index in breast specific gamma imaging and clinical features in patients with breast cancer[J].Chinese Journal of Clinical Medicine,2018,25(1):27-30 |
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Abstract:Objective:To analyze the correlations of semi-quantitative index, tumor to non-lesion ratio (T/N)in breast specific gamma imaging (BSGI) and clinical features in breast cancer. Methods:Totally 668 patients who underwent BSGI from January 2016 to July 2017 were enrolled. BSGI interpretation was assessed based on visual spectrum analysis and semi-quantitative analysis. The value of T/N in craniocaudal (CC) and mediolateral oblique(MLO) view was respectively obtained and the maximum value was selected for semi-quantitative analysis. Then the T/N value was compared among different pathological status. Results:Among 668 cases, there were 505 of malignant mass and 163 of benign mass, and the T/N value was obtained in all the cases. Analysis of receiver operating characteristic curve (ROC) showed that the sensitivity and specificity in diagnosing breast cancer was 84.53% and 74.02%, respectively, taking critical value of T/N as 1.81, and the AUC was 0.83 (SD=0.844, 95% CI 0.812-0.872). The T/N value was significantly different among patients with different tumor size (P=0.000), Ki-67 expression (P=0.039) and axillary lymph node metastases (P=0.02). Conclusions:The T/N value in BSGI is correlated with tumor size, Ki-67 expression, and axillary lymph node metastases, which can be used in predicting aggressiveness of breast cancer. |
keywords:breast specific gamma imaging breast cancer 99mTc-MIBI |
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