| Correlations between maximum standardized uptake value in 18F-FDG PET/CT and clinical pathological characteristics of moderately to poorly differentiated hepatocellular carcinoma |
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| Citation of this paper:.Correlations between maximum standardized uptake value in 18F-FDG PET/CT and clinical pathological characteristics of moderately to poorly differentiated hepatocellular carcinoma[J].Chinese Journal of Clinical Medicine,2018,25(1):31-34 |
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| Abstract:Objective：To investigate the correlations between the maximum standardized uptake value (SUVmax) in fluorodeoxyglucose F18 (18F-FDG) positron emission tomography-computed tomography (PET/CT) with the tumor differentiation, tumor size, and Ki-67 expression in patients with moderately and poorly differentiated hepatocellular carcinoma (HCC). Methods：The 18F-FDG PET/CT imaging data of 187 patients with single HCC lesion confirmed by pathology were evaluated retrospectively. According to the differentiation degree of tumor pathology, the patients were divided into moderate differentiation group, moderate-poor differentiation group, and poor differentiation group. According to the maximum diameter of the tumor, the patients were divided into ≤3 cm, 3-5 cm, 5-10 cm, and >10 cm group. According to the positive rate of Ki-67 expression, the patients were divided into high expression group (, , and ) and low expression group (－ and ＋). The SUVmax of primary tumor and the tumor to normal background ratio (TNR) were compared among groups. Furthermore, the correlations between SUVmax and pathological characteristics of HCC such as the maximum diameter of the tumor, tumor differentiation, and Ki-67 expression were analyzed. Results：The SUVmax and TNR were significantly different among moderate differentiation group (n=98), moderate-poor differentiation group (n=52) and poor differentiation group (n=37, both P<0.000 1), and the SUVmax was significantly correlated with the differentiation degree of tumor cells (r=-0.384 57, P<0.000 1). The maximum tumor diameter ≤3 cm group (n=70), 3-5 cm group (n=51), 5-10 cm group (n=43), and >10 cm group (n=23) had significant differences in SUVmax and TNR (both P<0.000 1), and the SUVmax was significantly correlated with the maximum tumor diameter (r=0.537 27, P<0.000 1). The SUVmax and TNR were both significantly different between Ki-67 low expression group (n=102) and Ki-67 high expression group (n=85, both P<0.000 1), and the SUVmax was significantly correlated with the expression of Ki-67 (r=0.370 96, P<0.000 1). Conclusions：In patients with moderately to poorly differentiated HCC, the SUVmax and TNR in 18F-FDG PET/CT are significantly associated with poor differentiation, large tumor size, and high expression of Ki-67. |
| keywords:hepatocellular carcinoma positron emission tomography-computed tomography fluorodeoxyglucose F18 |
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