Expression of E3 ubiquitin ligase UHRF2 in intrahepatic cholangiocarcinoma and its clinical significance |
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Citation of this paper:.Expression of E3 ubiquitin ligase UHRF2 in intrahepatic cholangiocarcinoma and its clinical significance[J].Chinese Journal of Clinical Medicine,2018,25(1):9-12 |
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Abstract:Objective:To explore the expression and clinical significance of ubiquitin-like with PHD and ring finger domains 2 (UHRF2) in intrahepatic cholangiocarcinoma (ICC). Methods:The expression of UHRF2 in 138 ICC was determined by immunohistochemistry, and the relationships between UHRF2 expression with prognosis and clinicopathological features of ICC were analyzed. Results:UHRF2 was highly expressed in ICC compared with paratumorous tissues. Level of UHRF2 was associated with high AFP level (P=0.010), poor tumor differentiation (P=0.026), lymph node metastasis (P=0.001), and advanced TNM stage (P=0.019). Elevated UHRF2 expression was suggested to be associated with poor prognosis and high recurrence rate in ICC patients (P<0.001), and multivariable analysis indicated that UHRF2 was of theprognostic indicators of ICC (P<0.05). Conclusions:High level of UHRF2 is related to the malignant phenotype of ICC, and can be a prognostic and recurrent indicator of postoperative patients. |
keywords:UHRF2 intrahepatic cholangiocarcinoma prognosis |
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