| Research progresses of PI3K/Akt signaling pathway in hepatic ischemia-reperfusion injury |
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| Citation of this paper:.Research progresses of PI3K/Akt signaling pathway in hepatic ischemia-reperfusion injury[J].Chinese Journal of Clinical Medicine,2018,25(1):103-107 |
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| Abstract:Liver ischemia-reperfusion injury is the leading cause of delayed recovery of liver function and dysfunction after operation. Some studies have shown that PI3K/Akt signaling pathway is activated during ischemia and reperfusion, which plays a protective role on the liver by inhibiting or enhancing the expressions of downstream target proteins. Therefore, PI3K/Akt signaling has become an important target pathway for preventing and improving hepatic ischemia-reperfusion injury. This review summarized the research progresses of PI3K/Akt signaling pathway in hepatic ischemia-reperfusion injury. |
| keywords:PI3K/Akt ischemia-reperfusion injury inflammatory response oxidative stress apoptosis autophagy |
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