| Abstract:Objective：To explore the efficacy of parecoxib combined with small supraumbilical incision in analgesia management after laparoscopic partial hepatectomy. Methods：From August 2013 to January 2017, 72 patients with liver tumors were enrolled and divided into two groups according to the tumor size, tumor location, type of operation, and incision length: patient-controlled intravenous analgesia (PCIA) group (n=36) and parecoxib group (n=36). All the cases underwent laparoscopic partial hepatectomy and the specimens were removed from small supraumbilical incision. The patients in PCIA group received postoperative analgesia using PCIA (sufentanil 250 μg + NS 250 mL, 1 mL/h pumping, bolus 6 mg/6 min), while those in parecoxib group were subjected to intravenous injection of parecoxib (40 mg i.v., immediately after surgery and q12 h×3 d postoperatively). The visual analogue scale (VAS) was used to assess the degree of postoperative pain. The time of bowel flatus and mobilisation, duration of catheter withdrawal and adverse effects were compared between the two groups. Results：There were no significant differences in the static VAS scores at time points of 1 h, 6 h, 12 h, 24 h, 48 h and 72 h after surgery and the dynamic VAS score at time points of 6 h, 12 h, 24 h, 48 h and 72 h after surgery between the two groups. The time of bowel flatus, time of mobilization and duration of catheter withdrawal in parecoxib group was (31.3±3.1), (22.1±2.8) and (19.1±1.4) h, respectively, all being significantly shorter than those in PCIA group (［48.2+4.3］, ［45.3±5.3］ and ［42.9±2.8］ h, all P<0.001). There were 6 cases of nausea and vomiting (16.7%), 3 cases of pruritus (8.3%), and 6 cases of dizziness (16.7%) in PCIA group, while no adverse effect was observed in parecoxib group. Conclusions：Analgesia using parecoxib combined with small supraumbilical incision has good analgesic effect in laparoscopic partial hepatectomy, which can facilitate a faster postoperative recovery with minimal adverse effects. |