| The correlation between cofilin 1 and prognosis of patients with primary hepatocellular carcinoma |
| Click here to download the full text |
| Citation of this paper:ZHAO Ying1△, ZHANG Chun-yan1, 2△, GUO Yi-chao1, DAI Qian1, WANG Bei-li1*, GUO Wei1, PAN Bai-shen1，2.The correlation between cofilin 1 and prognosis of patients with primary hepatocellular carcinoma[J].Chinese Journal of Clinical Medicine,2018,25(2):256-261 |
| Hits: 1881 |
| Download times: 975 |
| Author Name | Affiliation | | ZHAO Ying1△, ZHANG Chun-yan1, 2△, GUO Yi-chao1, DAI Qian1, WANG Bei-li1*, GUO Wei1, PAN Bai-shen1，2 | 1. Department of Clinical Laboratory, Zhongshan Hospital, Fudan University, Shanghai 200032, China
2. Department of Clinical Laboratory, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen 361015, Fujian, China |
|
| Abstract:Objective：To evaluate the prognosis value of cofilin 1 in hepatocellular carcinoma (HCC). Methods：A total of 126 postoperative specimens of the patients who were diagnosed as HCC and accepted resection in Zhongshan Hospital from December 2012 to May 2014 were collected in this study. The expression of cofilin 1 in specimens were detected by immunohistochemistry and ranked. The correlation between cofilin 1 and other clinical characteristics was analyzed. The GraphPad software was used to do survival analysis for the cofilin 1-low group and cofilin 1-high group in order to determine their impact on the disease free survival (DFS) and overall survival (OS). The risk factors of recurrence and survival after HCC resection were analyzed by Cox proportional hazard regression model. Results：The score of cofilin 1 expression was proved to be weakly positive correlated to preoperative AFP, tumor size, and BCLC grade (P<0.05). The survival analysis showed the statistically significant difference (both P<0.05) of the postoperative OS and disease free survival time between cofilin 1-high group and cofilin 1-low group; they were the same in the BCLC grade 0/A (both P<0.05) and tumor size<5 cm sub-group (both P<0.05), but not statistically significant in AFP≤20 ng/mL sub-group and no invasion sub-group. The single factor analysis of Cox proportional hazard regression model showed that the level of cofilin 1 was valuable in the judgment of postoperative recurrence and survival (both P<0.05). The homologous multiple-factor analysis showed that cofilin 1 was an independent risk factor for postoperative recurrence (HR=1.647, 95%CI 1.015-2.672) and survival (HR=2.412, 95%CI 1.696-4.940) of the patients with HCC. Conclusions：The expression level of cofilin 1 has significant correlation to the postoperative recurrence and poor survival. The high expression level of cofilin 1 is an independent risk factor for the postoperative recurrence of HCC, which can be used to assess the prognosis of patients with HCC resection. |
| keywords:carcinoma, hepatocellular cofilin 1 prognosis immunohistochemistry |
| HTML View Full Text View/Add Comment Download reader |
|
|
|