| Abstract:bjective：To investigate the risk factors of hyperuricemia (HUA), so as to provide the basis for effective control of serum uric acid (SUA). Methods：Totally 144 subjects with SUA≥420 μmol/L were recruited from physical examination population from January to December 2015 in four hospitals of Shanghai. At the time of enrollment, all the subjects were retested for SUA. Among them, 94 subjects with SUA≥420 μmol/L were taken as HUA group, and 50 subjects with SUA＜420 μmol/L as SUA normal group.All the subjects underwent questionnaires, anthropometric measurements and biochemical tests. Results：The SUA level was significantly higher in male than that in female (P<0.001), higher in drinkers than that in non-drinkers (P=0.01), and lower in those taking exercise than that in those without exercise (P=0.004). SUA level was positively correlated with systolic blood pressure(r=0.166, P=0.047), and negatively correlated with cereal intake (r=－0.215, P=0.01), serum vitamin C (VitC) concentration (r=－0.294, P<0.001)and serum hypoxanthine-guanine phosphoribosyl transferase (HGPRT) activity (r=－0.236, P=0.004). The linear regression equation of SUA was as follows: 452.870 (μmol/L) ＋1.598×systolic blood pressure (mmHg) －0.409×cereal intake(g) －2.231×serum VitC (mmol/L) －0.162×HGPRT (mmol/L). Conclusions：Cereal intake, serum VitC concentration and HGPRT activity are the protective factors of HUA, while systolic blood pressure is a risk factor. It is suggested that the people with HUA (especially men) should take optimal dietary, including adequate cereals, vegetables and fruits rich in VitC or oral supplements of VitC on the basis of balanced nutrition. It is also proposed that they should abstain from alcohol, take regular exercise and control systolic blood pressure for better control of SUA. |