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| Citation of this paper:.[J].Chinese Journal of Clinical Medicine,2017,24(6):920-923 |
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| Abstract:Objective：To investigate the corrleation between plasma homocysteine (Hcy) level and blood pressure variability in patients with essential hypertension.Methods：110 patients with essential hypertension were selected as the subjects. Blood biochemical indexes and ambulatory blood pressure were measured in all patients. The patients were divided into two groups according to the level of plasma Hcy: normal Hcy group (n=56) and high Hcy group (n=54). The parameters of age, sex, blood biochemistry and ambulatory blood pressure of the two groups were compared. The patients were divided into 4 groups according to different circadian rhythms: non-dipper group (n=45), dipper group (n=40), extreme dipper group (n=10), and anti-dipper group (n=15). The age, sex, plasma Hcy and blood biochemistry of the 4 groups were compared. The correlation between Hcy and ambulatory blood pressure parameters was analyzed.Results：The percentage of men was higher in the high Hcy group than that in the normal Hcy group (P＜0.001). The mean systolic blood pressure and mean diastolic blood pressure during the day, the night and 24 h in the high Hcy group were higher than those in the normal Hcy group (P<0.05). The HDL was lower in the high Hcy group than in the normal Hcy group (P＝0.036). The serum creatinine was higher in the high Hcy group than in the normal Hcy group (P＝0.001). The Hcy concentration was significantly higher in the anti-dipper group than in the other three groups (P＝0.001). Correlation analysis showed that there was a linear correlation between Hcy and daytime, nighttime, 24h mean systolic blood pressure and mean diastolic blood pressure (P<0.05), and there was no linear correlation between plasma Hcy and blood pressure variability or coefficient of variation.Conclusions：Plasma Hcy levels may be related to target organ damage caused by hypertension and abnormal circadian rhythm. Hcy may be a mediator for the link between BP variability and target damage, and plasma Hcy levels should be actively lowered in the treatment of hypertension. |
| keywords:homocysteine ambulatory blood pressure blood pressure variability circadian rhythm |
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