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Citation of this paper:.[J].Chinese Journal of Clinical Medicine,2017,24(3):334-338 |
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Abstract:Objective:To investigate the expression of metadherin (MTDH) in hepatocellular carcinoma (HCC) and its role in promoting HCC metastasis.Methods:The expression of MTDH in HCC and adjucent normal tissues was detected. Co-Immunoprecipitation (Co-IP) and mass spectrometry was used to investigate the protein complex involving MTDH. Results:The expression of MTDH was significantly higher in HCC tumors than that in corresponding normal liver tissues, and tumors with microvascular invasion, pathological satellites, poor differentiation, or TNM stage Ⅱ Ⅲ were prone to exhibit higher MTDH expression (P<0.01). The clinical outcome was poorer in the MTDH high group than that in the MTDH low group in both the 1 , 3 , 5 year overall survival rates (OS) and the 1 , 3 , 5 year cumulative recurrence rates (P<0.05). CO IP results showed that MTDH can form a complex with PRMT5.Conclusions:MTDH can accurately predict the poor outcome of HCC patients after surgery, and is a great independent prognostic indicator. |
keywords:metadherin hepatocellular carcinoma neoplasm metastasis prognosis |
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