| Abstract:Objective：To provide basis for the diagnosis and treatment of collagen type Ⅲ glomerualopathy by analyzing the clinical and pathological data of patients. Methods：After searching the data of the patients receiving renal biopsy from March 2007 to June 2015 in nephrology department, the clinical and pathological features of patients who were proven as collagen type Ⅲ glomerualopathy were analyzed. Results：Two male and two female patients aged (45.5±10.7) years old were included. None of the patients were reported to have positive familial history of any kidney diseases. None of them were found to have extra renal involvement. The most common clinical manifestations were proteinuria, hypertension and impaired renal function. Membrane proliferative glomerulonephritis, nodular glomerulosclerosis, focal segmental proliferative and sclerosis glomerulonephritis were found under the light microscopy. One of the patients was accompanied by IgA nephropathy. As for the follow up results, 1 case with minor declined eGFR and proteinuria less than 0.5 g/24 h remained stable in kidney function and proteinuria, 2 cases responding to glucocorticoids and immunosuppressive agents had improvement in renal function and partial remission of proteinuria, and 1 case developed into end stage renal disease and received hemodialysis. Conclusions：The sporadic cases of collagen type Ⅲ glomerualopathy may be underestimated in clinical practice, characterized by proteinuria, hypertension, and renal dysfunction. The light microscope pathological features of renal biopsy are various, and they are easy to be missed. Immunohistochemistry and electronic microscopy are essential to confirm the diagnosis. |