| Abstract:Objective：To observe the clinical efficacy of the different dose of oxycodone on shivering in caesarean section after combined spinal epidural anesthesia(CSEA). Methods：One hundred puerperae, ASA physical status Ⅰ-Ⅱ, scheduled for elective cesarean delivery under CESA were investigated. Puerperae who developed shivering after CSEA were randomly divided into five groups(n＝20 each) using a random number table: saline (Group C), tramadol 1 mg/kg（Group T）,oxycodone 20，40， and 80 μg/kg groups(Group O1,O2, and O3). All drugs were infused as a slow intravenous 〖BP(〗bolus by a blinded investigator 〖BP)〗after fetal delivery. The shivering intensity, the changes of hemodynamic and adverse reaction in right after medication （T1）, after medication in 5 min （T2）, 10 min（T3）, 15 min（T4）, 20 min（T5）, 30 min（T6）were recorded. Results：There was no statistical significance of the shivering intensity found in each group. The shivering controlled rate in Group T, Group O2, and Group O3 were significantly higher than Group C (90%, 50%, 75% vs15%，P＜0.05), and no statistical significance was found in Group T and Group O3 . No statistical significance of shivering controlled in T1 was found in Group T and that in Group O3 (80% vs 60%). The incidence of nausea and vomiting in Group T was higher than that in Group O3 (P＜0.05). Compared with other four groups, the satisfaction rate of postoperative analgesia in Group O3 was the highest (P＜0.05). Conclusions：Oxycodone 80 μg/kg produced a rapid and potent anti shivering effect, which can improve the satisfaction rate of postoperative analgesia. |