|
| Click here to download the full text |
| Citation of this paper:.[J].Chinese Journal of Clinical Medicine,2017,24(2):219-223 |
| Hits: 2190 |
| Download times: 1370 |
| Author Name | Affiliation | | 张巍1,2，龚高全1,2*，李长煜1,2，李国平1,2，陈颐1,2，王成刚1,2，王庆兵1,2，杨敏捷1,2，程洁敏1,2，王小林1,2 | 1. 上海市影像医学研究所，上海 200032
2. 复旦大学附属中山医院介入治疗科，上海 200032 |
|
| Abstract:Objective：To investigate the changes of plasma VEGF levels and its relationship with efficacy of transarterial chemoembolization (TACE) for patients with Barcelona Clinic Liver Cancer Staging (BCLC) stage B hepatocellular carcinoma, and also discuss its possible clinical significance. Methods：Peripheral blood samples were collected at 1 d before TACE and at 1, 3, 5, 7, 14, 30 d after TACE from 17 patients with BCLC stage B HCC. The relationship between plasma VEGF level and biological or imaging characteristics pre and post TACE were analyzed. Results：Compared with 1 day before surgery, the VEGF level at 1 day after surgery was improved, and decreased at 3 and 5 days after surgery, but increased significantly at 14 days after surgery (P＜0.05). Higher levels of plasma VEGF were observed in patients with fistula between hepatic artery and portal vein, or with tumor recurrence. Good response to TACE were observed in 10 patients, 7 patients with poor response. There were significant differences between two groups on plasma VEGF level at 14 d post TACE（P＜0.05）. Conclusions：The plasma VEGF level can be regarded as index to evaluate the efficacy of TACE for patients with BCLC B stage. |
| keywords:vascular endothelial growth factor hepatocellular carcinoma transcatheter arterial chemoembolization clinic liver cancer staging |
| HTML View Full Text View/Add Comment Download reader |
|
|
|