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Citation of this paper:.[J].Chinese Journal of Clinical Medicine,2017,24(2):233-237
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彭远飞,陈霏雨,王征,王晓颖,史颖弘,周俭,樊嘉* 复旦大学附属中山医院肝外科上海 200032 
Abstract:Objective:To examine the efficacy of analgesia using sequential patient controlled epidural analgesia (PCEA) parecoxib combined with modified Joel-Cohen incision for laparoscopic left lateral hepatectomy. Methods:From August 2013 to August 2016, 40 hepatocellular carcinoma (HCC) patients were enrolled and divided into PCEA group (n=20) and PCEA-parecoxib group (n=20). Patients in PCEA group received postoperative analgesia by using PCEA (bupivacaine 300 mg+fentanyl 500 μg+250 mL NS,4 mL/h pumping) , while those in PCEA-parecoxib group were subjected to PCEA and parecoxib (40 mg,iv,q12 h×2 d). The visual analog scale (VAS) was used to assess the degree of the postoperative pain. The times of bowel flatus, mobilisation, catheter withdrawal and adverse effects were compared. Results:There was no statistical significance of static VAS scores of PCEA group at 1 h、6 h、12 h、24、48 h and 72 h after surgery between two groups. The time of bowel flatus in PCEA-parecoxib group was (31±8.2) h, which was significantly shorter than that in PCEA group ([48±5.2] h, P<0.001). The time of mobilization in PCEA parecoxib group was (18±8.2) h, which was also significantly shorter than that in PCEA group ([26±5.2] h, P<0.001). Similarly, the time of catheter withdrawal in PCEA-parecoxib group was (26±8.2) h, which was significantly shorter than that in PCEA group ([68±5.2] h, P<0.001). There were 2 cases of nausea and vomiting and 1 case of hypotension in PCEA group while 1 case of nausea in PCEA-parecoxib group, and no incidence of hypotension. Conclusions:Analgesia using sequential PCEA-parecoxib combined with modified Joel-Cohen incision for laparoscopic left lateral hepatectomy is effective and equivalent to PCEA. It can facilitate a faster postoperative recovery and is worthy of wide application for laparoscopic left lateral hepatectomy.
keywords:laparoscopic left lateral hepatectomy  analgesia  patient controlled epidural analgesia  parecoxib
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