| Abstract:Objective：To investigate the therapeutic value of blood coagulation enzyme in the treatment of peptic ulcer bleeding by determining the activity level of eight plasma coagulation factors in plasma of patients with peptic ulcer bleeding. Methods：A total of 147 cases of peptic ulcer complicated with bleeding from April 2013 to April 2015 were recruited and divided into four groups: no anemia, mild anemia, moderate anemia, and severe anemia. 44 cases of peptic ulcer not complicated with bleeding and 81 cases of chronic gastritis were also recruited and the chronic gastritis cases were used as the control group. We determined the activity levels of the eight plasma coagulation factors: Ⅱ,Ⅴ,Ⅶ,Ⅷ,Ⅸ,Ⅹ,Ⅺ,Ⅻ, and the value of international normalized ratio (INR) in each group. Results：The INR value of each group was within the normal range, and there was no significant difference between the groups. Compared with the control group, the activity levels of coagulation factors Ⅱ and Ⅴ were significantly decreased in ulcer bleeding patients with mild and moderate anemia, and the levels of factors Ⅶ and Ⅹ were also significantly decreased in patients with mild, moderate and severe anemia. Meanwhile, the activity levels of factor Ⅷ were significantly increased in all four groups of ulcer bleeding patients with different degrees of anemia, and the activity levels of factor Ⅸ were also significantly increased in patients with no, mild and moderate anemia. Conclusions：The increased activity levels of coagulation factors Ⅷ and Ⅸ play a crucial role in maintaining the normal level of body coagulation function in peptic ulcer bleeding. Blood coagulation preparations can facilitate blood coagulation and hemostasis, and thus help treat peptic ulcer bleeding. |