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Citation of this paper:.[J].Chinese Journal of Clinical Medicine,2016,23(6):794-797 |
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Abstract:Objective:To explore the correlationship between the change of vascular endothelial growth factor (VEGF) level in peripheral blood and postoperative cognitive dysfunction (POCD) in patients with tracheal intubation under general anesthesia.
Methods:The elderly patients (age≥65) undergoing orthopaedics surgery with no cardiovascular disease and antidepressant disease history were selected. The cognitive function of patients was scored by mini mental state examination (MMSE) at 1 d before operation and 2 h after operation. There were two groups: POCD group (n=20) and control group (n=22). The level of VEGF in peripheral blood was detected in 10 min before anesthesia induction, 1 h during operation, 2 h and 1 d after operation, respectively.
Results:There was no significant difference in demographic data between the two groups. MMSE score was significantly lower 2 h after operation than before operation in POCD group (P<0.001), but there was no significant difference between pre operation and post operation in the control group. VEGF level was significantly increased 2 h after operation compared with that before operation in POCD group (P<0.01), but there was no significant changes between the control group and POCD group at other time points.
Conclusions:For the elderly patients undergoing orthopaedics operation under general anesthesia, the early POCD may be associated with the elevated expression of VEGF in peripheral blood 2 h after operation. |
keywords:cognition disorders general anesthesia vascular endothelial growth factor |
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