| Serum Level of Hydrogen Sulfide and Its Influential Factors in Patients Undergoing Maintenance Hemodialysis |
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| Citation of this paper:CHEN Yuemei,JIA Ping,ZOU Jianzhou,LIU Zhonghua,SHEN Bo,Lü Wenlü,CHEN Liming,DIND Xiaoqiang.Serum Level of Hydrogen Sulfide and Its Influential Factors in Patients Undergoing Maintenance Hemodialysis[J].Chinese Journal of Clinical Medicine,2016,23(1):86-89 |
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| Author Name | Affiliation | E-mail | | CHEN Yuemei | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Department of Nephrology, The Sencond Affliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China | | | JIA Ping | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | ZOU Jianzhou | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | LIU Zhonghua | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | SHEN Bo | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | Lü Wenlü | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | | | CHEN Liming | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China | chen.liming@zs-hospital.sh.cn | | DIND Xiaoqiang | Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Kidney Disease and Dialysis Institute of Shanghai, Shanghai 200032, China
Kidney Disease and Blood Purification Laboratory of Shanghai, Shanghai 200032, China | ding.xiaoqiang@zs-hospital.sh.cn |
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| Abstract:Objective: To investigate the serum level of hydrogen sulfide (H2S) and its influential factors in patients undergoing maintenance hemodialysis (MHD). Methods:Based on screening and exclusion criteria, 150 patients undergoing MHD were enrolled. Meanwhile, 17 healthy volunteers were collected as healthy controls. Venous blood samples of MHD patients were obtained before and after dialysis, and fasting blood samples were collected from healthy controls. The levels including serum H2S, nitric oxide (NO), endothelin-1 (ET-1), and sulfhemoglobin were detected and the correlations among them were analyzed. Results:The levels of serum H2S, NO, NO/ET-1 and sulfhemoglobin in patients undergoing MHD were significantly lower than those in healthy control group before dialysis (P<0.01), while, there was no significant difference regarding ET-1 and Vitamin B6 levels between these two groups (P>0.05). Before dialysis, serum H2S level was positively correlated with NO, NO/ET-1, sulfhemoglobin and eGFR (P<0.01), while negatively correlated to serum creatinine. After dialysis, serum H2S level increased significantly, while NO, NO/ET-1 decreased significantly. However, the levels of ET-1, sulfhemoglobin and Vitamin B6, compared with those before dialysis, did not change significantly after dialysis. Conclusions:Serum H2S level in patients undergoing MHD decreases significantly and it is significantly correlated with NO, sulfhemoglobin and renal function. Compared with that before hemodialysis, the serum H2S level increased significantly after hemodialysis. |
| keywords:Hydrogen sulfide Hemodialysis Nitric oxide |
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