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m6A甲基转移酶样3基因在泛癌中的表达及对肿瘤微环境的影响 |
费夏玮1, 张菊根1, 戴黎阳1, 吴振启1, 沈彦婷2,3, 李慧峰1
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1.复旦大学附属中山医院青浦分院泌尿外科, 上海 201700;2.上海交通大学医学院附属第九人民医院泌尿外科, 上海 200011;3.上海市浦东新区公利医院泌尿外科、男科学部, 上海 200135
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摘要: |
目的 分析m6A甲基转移酶样3(methyltransferase like 3,METTL3)基因在泛癌中的表达及对肿瘤微环境的影响。方法 在癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库下载多种癌症患者的基因测序结果及临床资料,分析METTL3基因在各类型肿瘤中的表达以及其与肿瘤微环境相关细胞浸润及预后的关系。结果 METTL3基因在大多数恶性肿瘤中表达上调,导致肝细胞癌和前列腺癌患者无进展生存期缩短(P<0.05)。肝细胞癌和前列腺癌中,METTL3表达与多种免疫细胞浸润水平及抑制性免疫检查点基因表达水平相关(P<0.05)。结论 METTL3基因表达增加导致肝细胞癌和前列腺癌患者的不良预后,可能通过促进免疫浸润及增加抑制性免疫检查点基因表达发挥作用。 |
关键词: m6A甲基转移酶样3 生物信息学 泛癌 肿瘤微环境 免疫浸润 |
DOI:10.12025/j.issn.1008-6358.2023.20231618 |
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基金项目:国家自然科学基金(62101319),上海市青浦区科技发展基金研究项目(QKY2020-23),上海市青浦区卫健委学科人才专项(YY2023-3). |
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Expression of m6A methyltransferase like 3 in pan-tumor and its effect on tumor microenvironment |
FEI Xia-wei1, ZHANG Ju-gen1, DAI Li-yang1, WU Zhen-qi1, SHEN Yan-ting2,3, LI Hui-feng1
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1.Department of Urology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, China;2.Department of Urology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China;3.Department of Urology and Andrology, Gongli Hospital, Navy Medical University, Shanghai 200135, China
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Abstract: |
Objective To analyze the expression of m6A methyltransferase like 3 (METTL3) gene in pan-tumor and its effect on tumor microenvironment. Methods The Cancer Genome Atlas (TCGA) database was used to analyze the gene sequencing and clinical data of patients with various tumors. The expressions of METTL3 gene in various tumors and its correlations with prognosis and tumor microenvironment were analyzed. Results METTL3 gene expression was upregulated in most malignancies, but only was associated with poor PFS of patients with hepatocellular carcinoma and prostate cancer (P<0.05). The expression of METTL3 gene was associated with the infiltration levels of many inmmunet cells in hepatocellular carcinoma and prostate cancer, as well as the expression levels of inhibitory immune checkpoint genes (P<0.05). Conclusions METTL3 gene overexpression could affect the prognosis of hepatocellular carcinoma and prostate cancer, which maybe associated with immune invasion and inhibitory immune checkpoints increased. |
Key words: m6A methyltransferase like 3 bioinformatics pan-tumor tumor microenvironment immune infiltration |