特应性皮炎痒觉敏化的机制研究进展

钱薇露; 蔡涛

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特应性皮炎痒觉敏化的机制研究进展
钱薇露¹, 蔡涛²
1.上海交通大学医学院附属同仁医院皮肤科, 上海 200336;2.重庆医科大学附属第一医院皮肤科, 重庆 400016

摘要:

特应性皮炎是一种慢性炎症性皮肤病，以瘙痒为主要表现。微小刺激即可诱发患者亢进的搔抓欲望，表现出痒觉敏化。痒觉敏化包括痒觉超敏及痒觉异化，痒觉敏化的发生主要是神经、免疫及皮肤屏障共同作用的结果，本文综述了近年来特应性皮痒觉敏化机制的研究进展。

关键词: 特应性皮炎痒觉超敏痒觉异化慢性瘙痒

DOI：10.12025/j.issn.1008-6358.2023.20230599

分类号:

基金项目:重庆市留学人员回国创业创新支持计划项目(cx2018148).

Research progress on the mechanism of itch sensitization in atopic dermatitis

QIAN Wei-lu¹, CAI Tao²

1.Department of Dermatology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China;2.Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Abstract:

Atopic dermatitis is a chronic inflammatory skin disease characterized by pruritus. Small stimulation can induce patient’s hyperactive desire to scratch, which is manifested as itch sensitization. Itch sensitization includes hyperknesis and alloknesis. The joint action of nerve, immunity and skin barrier leads to the occurrence of itch sensitization. This article reviews the research progress in the sensitization mechanism of atopic skin itching in recent years.

Key words: atopic dermatitis hyperknesis alloknesis chronic pruritus