| 摘要: |
| 目的 采用多光谱成像（multispectral imaging, MSI）技术分析肺腺癌肿瘤剖面和正常肺组织剖面的光谱特性差异，探讨其术中快速评估磨玻璃结节型肺腺癌浸润性成分的可行性。方法 本研究为前瞻性观察性队列研究，选择2022年8月复旦大学附属中山医院胸部CT诊断为肺磨玻璃结节的9例肺腺癌患者。通过对不同浸润性成分比例的肺腺癌及癌周正常肺组织剖面进行MSI，探讨不同浸润性成分比例的磨玻璃结节型肺腺癌的不同特征性光谱改变。结果 肺腺癌和正常肺组织剖面反射光谱特性曲线显示，肺腺癌相对于正常肺组织在血红蛋白3个特征吸收峰（420 nm、540 nm、580 nm）附近产生了特征性的三峰升高，并在450～510 nm处呈现特征性抬高。随着浸润性成分的增加，肺腺癌剖面相对于正常肺组织剖面血红蛋白含量差异增加。以正常肺组织为基准绘制的肺腺癌剖面反射光谱特性比值曲线出现逐渐增长的3个比值峰，且3个比值峰的相对高度可以反映肿瘤浸润性成分的含量。结论 影像学表现为磨玻璃结节的肺腺癌肿瘤剖面相对正常肺组织剖面具有特征性的光谱改变，对特征性光谱改变量化可快速预测肺腺癌病灶中浸润性成分的比例。 |
| 关键词: 肺磨玻璃结节 肺腺癌 浸润性成分 多光谱成像 |
| DOI：10.12025/j.issn.1008-6358.2023.20230465 |
| 分类号: |
| 基金项目:广东省季华实验室国家及部委重点实验室开放课题（X190111UZ190）. |
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| Feasibility analysis of rapid prediction of the invasive components of ground-glass nodularlung adenocarcinoma by multispectral imaging technology based on characteristic spectrum |
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YAO Guang-yu, WANG Qun, FAN Hong
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Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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| Abstract: |
| Objective To analyze the difference in spectral characteristics between lung adenocarcinoma tumor profile and normal lung tissue by multispectral imaging (MSI) technology, and to explore its feasibility to quickly evaluate the invasive components of ground-glass nodular lung adenocarcinoma during operation. Methods This study was a prospective observational cohort study. Nine patients with lung adenocarcinoma diagnosed as pulmonary ground-glass nodules by chest CT in Zhongshan Hospital affiliated to Fudan University at August 2022 were selected. To explore the different characteristic spectral changes of ground-glass nodular lung adenocarcinoma with different proportion of infiltrating components, MSI was performed on the profiles of lung adenocarcinoma and peripheral normal lung tissue sections. Results Through profile MSI, it was found that lung adenocarcinoma had a characteristic three-peak elevation near the three characteristic absorption peaks of hemoglobin (420 nm, 540 nm, 580 nm) compared with normal lung tissue. It also showed characteristic elevation at 450-510 nm. With the increase of infiltrating components, the difference in hemoglobin content between the lung adenocarcinoma profile and the normal lung tissue profile increased. The spectral ratio curve of lung adenocarcinoma profile drawn based on normal lung tissue had three gradually increasing ratio peaks, and the relative height of the three ratio peaks could reflect the content of tumor infiltrating components. Conclusions The lung adenocarcinoma tumor profile with ground-glass nodules on imaging has characteristic spectral changes compared to the normal lung tissue profile. Quantifying the characteristic spectral changes can quickly predict the proportion of invasive components in lung adenocarcinoma lesions. |
| Key words: pulmonary ground-glass nodules lung adenocarcinoma infiltrating components multispectral imaging |
