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| 阿尔茨海默病临床治疗研究进展 |
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黄强1, 桑绍明1, 潘晓黎1, 钟春玖1,2
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1.复旦大学附属中山医院神经内科, 上海 200032;2.复旦大学脑科学研究院, 脑科学协同创新中心, 医学神经生物学国家重点实验室, 上海 200032
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| 摘要: |
| 阿尔茨海默病（Alzheimer disease, AD）是最常见的神经退行性疾病之一，其高患病率将带来沉重的疾病负担。由于AD的发病机制尚不明确，目前有限的AD治疗药物只能延缓病情进展，却无法逆转病程。近年来，国内外进行了多个药物及非药物干预临床研究，对应的结果也相继披露。本文就近期开展的AD临床诊疗方法进行总结。 |
| 关键词: 阿尔茨海默病 药物研发 非药物治疗 |
| DOI：10.12025/j.issn.1008-6358.2023.20222310 |
| 分类号: |
| 基金项目:国家自然科学基金面上项目(82171408,82171411)，上海市市级科技重大专项(S2021-071). |
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| Advance on the clinical research of Alzheimer’s treatment |
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HUANG Qiang1, SANG Shao-ming1, PAN Xiao-li1, ZHONG Chun-jiu1,2
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1.Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China;2.Institutes of Brain Science, Collaborative Innovation Center for Brain Science, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
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| Abstract: |
| Alzheimer disease (AD) is one of the most prevalent neurodegenerative diseases, and its high morbidity would lead to heavy disease burden. As the pathogenesis of AD remains unclarified, current therapies could only slow down the disease progression rather than reverse the disease course. For decades, multiple non-drug treatments have been tested in the clinical trials as well as treatments involving novel developed drugs, and the corresponding outcomes have been disclosed. We reviewed the recently finished and on-going clinical trials focusing on AD in this article. |
| Key words: Alzheimer disease drug development non-drug treatment |
