摘要: |
过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptor γ,PPAR γ)是一种配体依赖的核受体转录因子,参与脂肪细胞分化、葡萄糖稳态和免疫反应等多种生物学过程。近年来,越来越多的研究强调了PPAR γ在哺乳动物胎盘中的重要作用。本文总结了PPAR γ在胎盘发育和病理性妊娠中的作用以及环境污染物通过PPAR γ对胎盘的毒性作用,以期提高对PPAR γ在胎盘中作用的认识,阐释PPAR γ对母胎健康的重要意义。 |
关键词: 过氧化物酶体增殖物激活受体γ 胎盘 妊娠期糖尿病 子痫前期 |
DOI:10.12025/j.issn.1008-6358.2023.20222140 |
分类号:R714 |
基金项目:上海市高水平地方高校建设项目——儿童发育与健康(DGJFYJK01),复旦大学双一流建设学科重点项目——儿童早期健康与维护平台建设(XM06221237). |
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The effect of peroxisome proliferator-activated receptor γ in placenta on maternal and fetal health: recent progress |
BAI Fan, ZHANG Jia-ling, GUI Yong-hao
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Department of Cardiovascular Medicine, Children's Hospital of Fudan University, Shanghai 201102, China
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Abstract: |
Peroxisome proliferator-activated receptor γ (PPAR γ) is a nuclear receptor of ligand-dependent transcription factor involved in diverse biological processes including adipocyte differentiation, glucose homeostasis, and immune response. In recent years, a growing number of studies have highlighted the essential role of PPAR γ in the mammalian placenta. This article reviews the recent progress in the research of PPAR γ in the development of placenta, pathological pregnancy and the toxic effects of environmental pollutants on the placenta through PPAR γ, in order to improve the awareness of PPAR γ in the placenta and illuminate the significance of PPAR γ in pregnancy. |
Key words: peroxisome proliferator-activated receptor γ placenta gestational diabetes mellitus preeclampsia |