| 摘要: |
| HSPA9基因在多种肿瘤中高表达，被证实与肿瘤细胞的增殖和侵袭性高度相关。近年来，针对HSPA9基因在多种肿瘤中的表达及其涉及的下游通路的研究逐渐增多，并且相关联的临床特征分析均提示HSPA9的表达可作为独立的临床预测因子。本文对HSPA9基因在肿瘤中表达和功能的研究成果作简要综述，旨在为HSPA9基因未来作为靶向治疗靶点提供理论基础。 |
| 关键词: HSPA9基因 肿瘤 基因表达 下游通路 |
| DOI：10.12025/j.issn.1008-6358.2023.20220629 |
| 分类号:R 73 |
| 基金项目:上海市卫生健康委员会科研课题(20204Y0228). |
|
| Progress on the expression and function of the HSPA9 gene in tumors |
|
BIAN Yun-yi, ZHAN Cheng, BI Guo-shu, LIANG Jia-qi, SHAN Guang-yao, FAN Hong
|
|
Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
|
| Abstract: |
| HSPA9 gene is over-expressed in a variety of tumors, and it has been proved to be highly correlated with the proliferation and invasion of tumor cells. In recent years, there have been several studies on the expression of the HSPA9 gene in tumors and the downstream pathways involved, and analysis of related clinical characteristics has suggested that the expression of HSPA9 can be used as an independent clinical predictor. This article reviews the research results on the expression and function of HSPA9 gene in tumors to provide a theoretical basis for HSPA9 gene as a target for targeted therapy in the future. |
| Key words: HSPA9 gene tumor gene expression down-stream pathways |
