Abstract:
Objective To evaluate the efficacy of compound lidocaine cream combined with oxycodone in the prevention of catheter-related bladder discomfort (CRBD) after transurethral resection of bladder tumor (TURBT).
Methods A total of 135 male patients receiving TURBT under general anesthesia from July 2020 to December 2020 were randomly divided into three groups: compound lidocaine cream group (group L), oxycodone group (group O) and compound lidocaine cream combined with oxycodone group (group LO), with 45 cases of each group. The urethral catheter of patients in group L were lubricated with compound lidocaine cream, and patients in group O were treated with water-soluble lubricant and intravenously injected oxycodone 0.05 mg/kg 20 minutes before the end of the operation, and patients in group LO were treated with the two methods described above. The incidence, symptoms and severity of CRBD were recorded as soon as the patients entered the PACU (T1), 30 min (T2) and 60 min (T3) after entering the PACU. During the recovery period, adverse reactions and hemodynamic indexes were recorded.
Results A total of 12 patients were excluded and finally 123 cases were analyzed. At T1, the severity rate of CRBD in group LO was significantly lower than that in group L (P<0.017), and at T2, the incidence of CRBD in group LO was significantly lower than that in group L (P<0.017). There was no significant difference in the incidence and severity of CRBD between the group LO and the group O (P>0.017). At T1, the incidence of "pain" in group LO was significantly lower than that in group L (RR=5.744, 95%CI 1.810-18.203) and group O (RR=4.000, 95%CI 1.216-13.157), and the incidence of "flatulence" in group LO was significantly lower than that in group L (RR=2.769, 95%CI 1.300-5.900) and group O (RR=2.286, 95%CI 1.049-4.978). There was no significant difference in the incidence of adverse reactions and hemodynamic parameters among the three groups.
Conclusions In male patients undergoing TURBT, compared with single administration of compound lidocaine cream, the combination of compound lidocaine cream and oxycodone could reduce the incidence of CRBD in the early stage of recovery, and relieve the uncomfortable symptoms of "pain" and "flatulence".