摘要: |
外阴硬化性苔藓是一种慢性非肿瘤性皮肤病变,可发生于任何年龄的女性。该病主要表现为外阴瘙痒、疼痛,皮肤黏膜萎缩、发白,小阴唇逐渐萎缩消失。患者外阴癌风险显著提高。其病因仍不明确,潜在致病因素包括自身免疫、遗传因素、性激素影响、感染因素、氧化应激等多个方面。本文对外阴硬化性苔藓病因进行总结与归纳。 |
关键词: 外阴硬化性苔藓 病因 自身免疫 氧化应激 |
DOI:10.12025/j.issn.1008-6358.2022.20210986 |
分类号:R758.65 |
基金项目:上海市自然科学基金(20ZR1470900). |
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Advances in etiology of vulvar lichen sclerosus |
SUN Xiao-yi1, XU Cong-jian2, SUI Long3, CONG Qing3
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1.Clinical Medical School of Shanghai Medical College, Fudan University, Shanghai 200032, China;2.Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China;3.Medical Center of Diagnosis and Treatment for Cervical Disease, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
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Abstract: |
Vulvar lichen sclerosus is a chronic nonneoplastic skin disease, which can occur in women at any age. The main clinical manifestactions of this disease include pruritus and pain of vulva, atrophy and whitening of skin and mucosa, atrophy and disappearance of labia minora. The risk of vulvar cancer increased significantly in these patients. The etiology is still unclear. Potential pathogenic factors of vulvar lichen sclerosus include autoimmunity, genetic factors, sex hormone influence, infection factors, oxidative stress, and so on. This paper summarizes the advances in etiology of vulvar lichen sclerosus. |
Key words: vulvar lichen sclerosus etiology autoimmunity oxidative stress |