摘要: |
右美托咪定(dexmedetomidine,DEX)为α2肾上腺素能受体(α2-AR)激动剂,是目前临床常用的药物,其可能通过减轻血流动力学改变、减轻氧化应激反应、抑制心肌细胞凋亡、减轻心肌炎症反应、改善心肌缺血再灌注后微循环功能障碍、保护线粒体结构和功能、抗心律失常作用等机制对围手术期患者的心血管系统产生作用。本文就右美托咪定在心血管方面的保护机制、临床应用及其导致的不良反应作一综述。 |
关键词: 右美托咪定 心血管系统 临床应用 |
DOI:10.12025/j.issn.1008-6358.2022.20210890 |
分类号:R614 |
基金项目:国家自然科学基金(82001473). |
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Progress of cardiovascular protective effects of dexmedetomidine |
QIU Zhi-yun, WANG Hui-lin, XIA Mu-chao, YUE Ying, GU Jia-hui, MIAO Chang-hong
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Department of Anesthesiology, Fudan University, Zhongshan Hospital, Shanghai 200032, China
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Abstract: |
Dexmedetomidine, an α-2 adrenoreceptor (α2-AR) agonist, is a commonly used drug at present, which can protect the cardiovascular system during the perioperative period. The possible mechanisms include decreasing the hemodynamic change, inhibiting cardiomyocyte apoptosis, reducing myocardial inflammatory response, improving microcirculation dysfunction after myocardial ischemia-reperfusion, protecting mitochondrial structure and function, and anti-arrhythmia. This review focuses on the mechanisms of protection, clinical applications, and adverse reactions of dexmedetomidine in the cardiovascular system. |
Key words: dexmedetomidine cardiovascular system clinical application |