摘要: |
大量证据表明肾脏疾病与炎症小体之间存在关联,尤其是核苷酸结合寡聚化结构域样受体家族含pyrin结构域蛋白3(nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3,NLRP3)炎症小体。NLRP3炎症小体在诱导肾脏炎症和纤维化中起重要作用,靶向NLRP3炎性小体组成成分的小分子抑制剂是治疗肾脏相关疾病的潜在药物。本文综述了近年NLRP3炎症小体在肾脏疾病中作用的新发现以及以NLRP3炎症小体为靶标的新策略。 |
关键词: NLRP3炎症小体 肾脏疾病 急性肾损伤 慢性肾损伤 |
DOI:10.12025/j.issn.1008-6358.2022.20210133 |
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Research progress of NLRP3 inflammasome as a potential therapeutic target for kidney disease |
ZHAO Ting, ZHANG Fang-fei, WANG Nian-song, WANG Feng
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Department of Nephrology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
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Abstract: |
Plenty of evidence suggested an association between kidney disease and inflammasomes, especially nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasomes. NLRP3 inflammasomes play an important role in renal inflammation and fibrosis. Small molecule inhibitors targeting the components of NLRP3 inflammasomes are potential options for the treatment of kidney-related diseases. This article reviews the new findings of the role of NLRP3 inflammasomes in kidney disease in recent years and new strategies targeting NLRP3 inflammasomes. |
Key words: NLRP3 inflammasome kidney disease acute kidney injury chronic kidney disease |