摘要: |
目的:探讨偏头痛患者前驱期症状特点、与头痛预后的关系及预警能力。方法:回顾性分析2018年1月至2020年8月确诊的偏头痛患者共107例,依据有无前驱期进行分组,比较2组前驱期常见症状,分析不同前驱期症状对头痛发作的预警能力。结果:107例患者中,有前驱期症状组68例(63.55%),无前驱期症状组39例(36.45%)。有前驱期症状组疼痛视觉模拟评分(visual analog scale,VAS)评分为(7.66±0.21)分、偏头痛特异生活质量问卷(MSQ,2.1版)评分为(72.01±14.49)分;无前驱期症状组VAS评分(6.98±0.27)分、MSQ评分为(58.76±15.33)分,两组间差异有统计学意义(P<0.05)。有前驱期症状组较无前驱期症状组疼痛程度更高、生活质量受损程度更严重。偏头痛前驱期最常见症状为颈僵痛(50.00%)、疲劳感(45.59%)和频繁打哈欠(41.18%);在头痛预警方面,颈僵痛的预警价值最高,其次是频繁打哈欠。有高预警症状者头痛持续时间亦较长(P<0.05)。结论:偏头痛有前驱期症状可能预示更重的疼痛程度及更差的生活质量,以颈僵痛及频繁打哈欠常见,其中颈僵痛对头痛具有更高的预警价值。 |
关键词: 头痛 偏头痛 前驱期症状 非头痛症状 预警 |
DOI:10.12025/j.issn.1008-6358.2021.20202321 |
分类号:R747.2 |
基金项目:上海市科学技术委员会"科技创新行动计划"(17411950104),上海市科学技术委员会生物医药领域科技支撑项目(19441907500),海军军医大学长征医院为军服务创新项目(2020CZWJFW10). |
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Relationship between different prodromal symptoms and the prognosis of migraine and its value in headache early warning |
XU Jin, PENG Hua, HE Bin, ZHUANG Jian-hua, YIN You
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Department of Neurology, Changzheng Hospital, Naval Medical University, Shanghai 200003, China
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Abstract: |
Objective: To explore the characteristics of prodromal symptoms, the relationship between prodromal symptoms and headache prognosis and early warning ability in patients with migraine. Methods: A total of 107 patients with migraine diagnosed from January 2018 to August 2020 were analyzed retrospectively. They were divided into two groups according to whether they had prodromal period or not, and the characteristic differences between the two groups were compared. Results: Among the 107 patients, 68 cases (63.55%) had prodromal symptoms and 39 cases (36.45%) had no prodromal symptoms. The pain visual analogue scale (VAS) score and migraine specific quality of life questionnaire (MSQ,2.1) in the group with prodromal symptoms were (7.66±0.21) and (72.01±14.49) points, respectively. In the group without prodromal symptoms, the scores of VAS and MSQ were (6.98±0.27) and (58.76±15.33) points, respectively. There were significant difference between the two groups (P<0.05). Compared to the group without prodromal symptoms, the group with prodromal symptoms had a higher degree of pain and a more serious degree of impaired quality of life. The most common symptoms of prodromal migraine were neck stiffness (50.00%), fatigue (45.59%) and frequent yawning (41.18%). In terms of headache warning, neck stiffness had the highest warning value among the three, followed by frequent yawning. People with high-warning symptoms had longer duration of headache (P<0.05). Conclusions: The prodromal symptoms of migraine may indicate more severe pain and worse quality of life, and the neck stiffness and frequent yawning are common; Neck stiffness has a higher warning value for headaches, and it should draw more attention from physicians. |
Key words: headache migraine prodromal period symptoms non-headache symptoms warning |