摘要: |
白塞综合征(BS)是一种以复发性口腔溃疡、外阴溃疡、皮肤病变和葡萄膜炎等为特征的变异性血管炎。Th细胞和Treg细胞失衡及各类细胞因子异常在其发病过程中发挥了重要作用。NLRP3炎症小体是固有免疫系统的重要成分,可以介导Caspase-1激活,促进细胞因子IL-1β、IL-18分泌,进而参与细胞损伤。研究发现,NLRP3炎症小体的异常激活在多种自身免疫性疾病的发生和进展中发挥着重要作用。近来,有关NLRP3炎症小体与BS相关性研究受到广泛关注。本文将对NLRP3炎症小体的结构和功能以及NLRP3炎症小体在白塞综合征中的研究进展综述,旨在为BS的发病机制提供新的研究思路。 |
关键词: 白塞综合征 NLRP3 炎症小体 细胞因子 |
DOI:10.12025/j.issn.1008-6358.2021.20202163 |
分类号: |
基金项目:国家自然科学基金项目(面上项目81871276);上海申康医院发展中心临床科技创新项目(SHDC12017129) |
|
Research of NLRP3 Inflammasomes in Beh?et’s Syndrome |
HOU Cheng-cheng, GUAN Jian-long
|
Huadong Hospital
|
Abstract: |
Beh?et's Syndrome(BS) is a chronic, recurrent variant vasculitis characterized by the recurrent oral and genital ulcers, skin lesions, uveitis, etc. The imbalance of Th cells and Treg cells and the abnormality of various cytokines play an important role in the pathogenesis. NLRP3 inflammasomes is a vital component of the innate immune system, which can mediate the activation of caspase-1; promote the secretion of IL-1βand IL-18; participate in microbial infection and cells damage. Numerous studies have found that abnormal activation of NLRP3 inflammasomes plays an important role in the occurrence and progression of various autoimmune diseases. Recently, researches on the association between NLRP3 inflammasomes and BS have received extensive attention. In this review, we will introduce the structure and function of NLRP3 inflammasomes and the studies of NLRP3 inflammasomes in BS, aiming to provide new research ideas for the pathogenesis of BS. |
Key words: Behcet’s Syndrome NLRP3 inflammasomes cytokines |