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NT-proBNP水平对非ST抬高型急性冠脉综合征患者冠脉闭塞病变的诊断价值

Diagnostic value of NT-proBNP level forcoronary artery occlusion in patients with non-ST-elevation acute coronary syndrome

    摘要
  • 摘要:
    目的 探讨N端脑钠肽前体（NT-proBNP）水平与非ST抬高型急性冠脉综合征（NSTE-ACS）患者冠状动脉闭塞病变的相关性及对病变的评估价值。
    方法 选取2017年12月至2019年12月泰安市中心医院收治的NSTE-ACS患者223例，根据冠脉造影的结果分为非闭塞病变组（n=156）和闭塞病变组（n=67）。分析2组NT-proBNP水平差异，采用logistic回归分析闭塞病变的危险因素，采用受试者工作特征（ROC）曲线评估NT-proBNP对闭塞病变的诊断价值。
    结果 与非闭塞病变组相比，闭塞病变组NT-proBNP水平显著升高，差异有统计学意义（P < 0.001）；多因素logistic回归分析显示，NT-proBNP水平升高是NSTE-ACS闭塞病变的危险因素（OR=1.011，95% CI 1.001~1.012，P=0.002）。NT-proBNP诊断闭塞病变的ROC曲线下方面积（AUC）为0.724（95% CI0.638~0.810），最佳界值点为149.50 ng/L，灵敏度为80.6%，特异度为61.5%。
    结论 在NSTE-ACS闭塞病变中，NT-proBNP水平升高，对NSTE-ACS的闭塞病变有一定诊断价值。

     

    Abstract:
    Objective To explore the correlation between NT-proBNP level and coronary artery occlusion in patients with the non-ST-elevation acute coronary syndrome (NSTE-ACS) and its evaluation value.
    Methods 223 patients with NSTE-ACS admitted to Tai'an Central Hospital from December 2017 to December 2019 were selected. According to the results of coronary angiography, the patients were divided into non occlusive disease group(n=156) and occlusive disease group(n=67). The NT-proBNP level of the two groups was measured and compared. The risk factors of coronary occlusion were analyzed by logistic regression, and the diagnostic value of NT-proBNP for NSTE-ACS occlusive lesions was evaluated by ROC curve.
    Results Compared with the non-coronary occlusion group, the level of NT-proBNP in the coronary occlusion group was significantly higher (P < 0.001); multivariate logistic regression analysis showed that high level of NT-proBNP was an independent risk factor for the presence of coronary occlusion in NSTE-ACS (OR=1.011, 95% CI 1.001-1.012, P=0.002). The area under ROC curve of NT-proBNP was 0.724 (95% CI 0.638-0.810), and the best cut-off point was 149.50 ng/L, sensitivity 80.6%, specificity 61.5%.
    Conclusions In NSTE-ACS patients with coronary occlusion, the level of NT-proBNP is increased. It is of certain value to the diagnosis of NSTE ACS occlusion.

     

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