摘要: |
目的:探讨女性未绝经状态与冠心病植入药物支架后结局的关系。方法:回顾性分析2008年1月至2014年12月复旦大学附属中山医院数据库中小于55岁、植入药物支架的143例女性冠心病患者病例资料。根据介入手术时的绝经状态分为未绝经女性组(n=50)和已绝经女性组(n=93)。结果:与已绝经女性组相比,未绝经女性组年龄更小、冠心病家族史比例更高,但两组其他常见冠心病危险因素差异无统计学意义。两组患者起病方式和手术特点差异无统计学意义。中位随访时间823 d。两组主要心脏不良事件(major cardiac adverse events,MACEs)的发生率差异无统计学意义,无事件生存率差异无统计学意义。Cox回归分析显示,肾小球滤过率下降和多支血管病变是MACEs的预测因素(P<0.05),未绝经状态不是MACEs的预测因素。结论:在女性冠心病患者中,未绝经状态不是MACEs的影响因素。 |
关键词: 冠心病 经皮介入治疗 药物支架 女性 绝经 |
DOI:10.12025/j.issn.1008-6358.2021.20201815 |
分类号:R541.4 |
基金项目:国家重点研发计划(2019YFC0840601). |
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Effect of menopausal status on long-term outcome of women undergoing drug-eluting stent implantation |
WANG Xiang-fei, DORJE Ta-shi, WANG Qi-bing, FAN Bing, QIAN Ju-ying, GE Lei, MA Jian-ying, ZHANG Feng, YAO Kang, GE Jun-bo
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Department of Cardicology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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Abstract: |
Objective: To explore the relationship between menopausal status and long-term outcome of patients with coronary heart disease (CHD) after drug-eluting stent implantation. Methods: The data of 143 patients with CHD who were less than 55 years old and implanted with drug-eluting stents in Zhongshan Hospital, Fudan University from January 2008 to December 2014 were retrospectively analyzed. According to the status of menopause, patients were divided into premenopausal women group (n=50) and postmenopausal women group (n=93). Results: Compared with the postmenopausal women, the premenopausal women were younger, and had a higher rate of positive family history of CHD. The median follow-up time was 823 days. The incidence of major cardiac adverse events (MACEs) was not significantly different between the two groups. The event-free survival rate was not significantly different between the two groups. Cox regression analysis showed that the independent predictors of MACEs included the multi-vessel disease and lower estimated GFR other than menopausal status. Conclusions: In women with CHD, the premenopausal status might not be a influence factor for MACEs. |
Key words: coronary artery disease percutaneous coronary intervention drug-eluting stent female menopause |