摘要: |
造影剂肾病是指因血管内碘化造影剂暴露而继发的急性肾损伤。近年来,越来越多的循证医学证据证实他汀类药物在防治造影剂肾病中的有效性和安全性。本文从他汀类药物剂量、种类、用药时间及患者的个体差异对疗效的影响,以及其保护肾脏的可能机制等方面对其预防造影剂肾病的最新研究进展作一综述。 |
关键词: 造影剂肾病 他汀类药物 影响因素 保护机制 |
DOI:10.12025/j.issn.1008-6358.2022.20201739 |
分类号:R692 |
基金项目:国家自然科学基金(81770741,81570603). |
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Research progress of statins in the prevention and treatment of contrast-induced nephropathy |
ZHOU Lu1, ZHAO Qing2, WANG Feng1
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1.Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China;2.Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China
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Abstract: |
Contrast-induced nephropathy refers to acute kidney injury secondary to exposure to intravascular iodinated contrast agent. In recent years, a lot of evidence has confirmed the effectiveness and safety of statins in the prevention and treatment of contrast-induced nephropathy. This article reviews the latest research progress of statins in the prevention of contrast-induced nephropathy from the aspects of dose, type, duration of medication, impact of individual differences on the efficacy of statins, and the possible mechanism of its kidney protection effects.. |
Key words: contrast-induced nephropathy statins influencing factors protective mechanism |