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基于PET/CT后处理工作站行SPECT/CT骨定量分析的可行性 |
余浩军1,2,3, 张一秋1,2,3, 李蓓蕾1,2,3, 石洪成1,2,3
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1.复旦大学附属中山医院核医学科, 上海 200032;2.复旦大学核医学研究所, 上海 200032;3.上海市影像医学研究所, 上海 200032
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摘要: |
目的: 探讨单光子发射计算机断层成像术(SPECT/CT)和正电子发射断层成像术(PET/CT)后处理工作站对SPECT/CT骨定量分析数据进行定量分析结果的一致性,对比不同工作站测量病灶的最大标准摄取值(the maximum standardized uptake value,SUVmax)、平均标准摄取值(the average standardized uptake value,SUVave)、病灶体积和平均CT值的异同。方法: 回顾分析行全身骨显像及定量SPECT/CT显像且在SPECT/CT显像范围内目测不超过2个显像剂浓聚病灶的患者40例。男性23例,女性17例,年龄37~88岁,平均年龄(60.3±10.2)岁,共获得50个病灶。首先,采用“SyngoMI VB10B SPECT/CT工作站”三维(three-dimensional,3D)等高线容积感兴趣区(volume of interest,VOI)测量法,获得SUVmax、SUVave、病灶体积和平均CT值。然后,将数据导入PET/CT后处理工作站“uWS-MI”医学影像处理软件,采用自带的3D椭球体VOI测量法、自适应阈值分割测量法和固定阈值分割测量法进行上述指标的测量,分别比较其与“SyngoMI VB10B SPECT/CT工作站”3D等高线VOI测量法测得的SUVmax、SUVave、病灶体积和平均CT值的差异是否有统计学意义。结果: 3D椭球体VOI测量法与3D等高线VOI测量法比较两组病灶SUVmax完全一致,但SUVave(t=9.841,P<0.001)、病灶体积(t=-4.314,P<0.001)和平均CT值(t=12.554,P<0.001)比较差异有统计学意义。自适应阈值分割测量法和固定阈值分割测量法对其中1例患者的毗邻腰椎和骶骨2处病灶无法准确分割。与3D等高线VOI测量法比较,其他39例患者的48处病灶的SUVmax完全一致。自适应阈值分割测量法与3D等高线VOI测量法比较,48处病灶的2组SUVave(t=-0.723,P=0.473)、病灶体积(t=-1.407,P=0.166)和平均CT值(t=-0.735,P=0.466)的差异均无统计学意义。固定阈值分割测量法与3D等高线VOI测量法比较,48处病灶的2组SUVave(t=2.947,P=0.473)、病灶体积(t=-2.003,P=0.051)的差异均无统计学意义,而平均CT值(t=-4.71,P<0.001)的差异有统计学意义。结论: PET/CT后处理工作站“uWS-MI”医学影像处理软件对于定量SPECT/CT骨显像数据具有良好的兼容性,其3种测量方法对于SUVmax的测量均能获得一致的结果,但自适应阈值分割测量法和固定阈值分割测量法对于毗邻病灶的分割提取相应参数有一定的局限性。对于SUVave、病灶体积和平均CT值的数值会受不同测量方法的影响而不同。其中,自适应阈值分割测量法与3D等高线VOI测量法的测量结果差异无统计学意义。 |
关键词: 定量SPECT/CT 标准摄取值 “uWS-MI”医学影像处理软件 |
DOI:10.12025/j.issn.1008-6358.2021.20201243 |
分类号:R445.6 |
基金项目:上海市卫生健康委员会科研课题面上项目(201740201),上海市2020年度“科技创新行动计划”技术标准项目(20DZ2201800),上海市医苑新星青年医学人才培养(医学影像项目)资助计划(沪卫人事[2020]087号),上海市临床重点专科项目(shslczdzk03401),西门子医疗科技有限公司资助项目(H2019-101). |
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Feasibility study of SPECT/CT bone quantitative analysis using PET/CT post-processing workstation |
YU Hao-jun1,2,3, ZHANG Yi-qiu1,2,3, LI Bei-lei1,2,3, SHI Hong-cheng1,2,3
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1.Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China;2.Nuclear Medicine Institute of Fudan University, Shanghai 200032, China;3.Shanghai Institute of Medical Imaging, Shanghai 200032, China
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Abstract: |
Objective: To investigate the consistency of SPECT/CT and PET/CT post-processing workstations for quantitative analysis of SPECT/CT bone quantitative data, and compare the similarities and differences of the maximum standardized uptake value (SUVmax), the average standardized uptake value (SUVave), volume and average CT value of the lesions measured by different workstations.Methods: Forty patients who underwent whole-body bone scintigraphy and quantitative SPECT/CT imaging, and had no more than two hot spots within SPECT/CT imaging range were retrospectively analyzed. A total of 50 lesions were obtained. Three-dimensional (3D) isocontour volume of interest (VOI) method of "SyngoMI VB10B" SPECT/CT workstation was used to obtain the SUVmax, SUVave, volume, and average CT value of the lesions. Then the data were imported into the "uWS-MI" medical image processing software of PET/CT post-processing workstation. The above parameters were measured by 3D ellipsoid VOI method, adaptive threshold segmentation method, and fixed threshold segmentation method, respectively. The SUVmax, SUVave, volume, and average CT value measured by the three processing methods of "uWS-MI" workstation and 3D isocontour VOI method of "SyngoMI VB10B" SPECT/CT workstation were compared respectively to see if the difference was statistically significant.Results: The SUVmax measured by the 3D ellipsoid VOI method of "uWS-MI" workstation and the 3D isocontour VOI method of "SyngoMI VB10B" SPECT/CT workstation were completely consistent, but SUVave (t=9.841, P<0.001), lesion volume (t=-4.314, P<0.001) and average CT value (t=12.554, P<0.001) were significantly different. The adaptive threshold segmentation method and the fixed threshold method of "uWS-MI" workstation can not accurately segment two adjacent lesions of the lumbar spine and sacrum in one patient. Comparing with the 3D isocontour VOI method of "SyngoMI VB10B" SPECT/CT workstation, the SUVmax of 48 lesions in 39 other patients was completely the same. Comparing the adaptive threshold segmentation method of "uWS-MI" workstation with the 3D isocontour VOI method of "SyngoMI VB10B" SPECT/CT workstation, the SUVave (t=-0.723, P=0.473), lesion volume (t=-1.407, P=0.166), and average CT value (t=-0.735, P=0.466) of the 48 lesions were not statistically different. Comparing the fixed threshold measurement method of "uWS-MI" workstation with the 3D isocontour VOI method of "SyngoMI VB10B" SPECT/CT workstation, the SUVave (t=2.947, P=0.473) and lesion volume (t=-2.003, P=0.051) of 48 lesions were not statistically different, while the difference in average CT value (t=-4.71, P<0.001) was statistically significant.Conclusions: "uWS-MI" medical image processing software of PET/CT post-processing workstation has good compatibility with the quantitative data of SPECT/CT bone imaging. The three methods of PET/CT post-processing workstation can obtain consistent results for the measurement of SUVmax. However, the adaptive threshold segmentation method and fixed threshold measurement method of "uWS-MI" workstation have certain limitations for extracting the corresponding parameters for the segmentation of adjacent lesions. The values of SUVave, volume, and average CT value will be affected by different measurement methods. There is no significant difference between the adaptive threshold segmentation method of "uWS-MI" workstation and the 3D isocontour VOI method of "SyngoMI VB10B" SPECT/CT workstation. |
Key words: quantitative SPECT/CT standardized uptake value "uWS-MI" medical image processing software |