摘要: |
目的:探讨骨显像SPECT/ CT骨定量分析国人脊柱及骨盆的标准化摄取值的正常分布。
方法:回顾性分析500例入组肿瘤患者行99mTc-MDP骨定量xSPECT/CT显像数据。在正常颈、胸、腰、骶椎及骨盆骨骼处勾画感兴趣区,测量最大(maximum)和平均(mean)SUV(SUVmax和SUVmean),统计分析SUV值在正常骨骼的分布及其与年龄、身高、体重和CT值的相关性。结果:SUVmax和SUVmean在第6颈椎最大,分别为7.4±2.4和6.0±2.1,在第3骶椎最小,分别为4.4±2.0和2.2±1.1。脊柱及骨盆SUVmax和SUVmean的变异系数(CV)大小相近,分别在31.6%~45.6%和34.1%~52.7%之间,骨盆组成骨SUVmax(CV骨盆=42.4% 、CV脊柱=35.0%)和SUVmean (CV骨盆=52.7%、CV脊柱=38.3%)个体间变异略大于脊柱。骨骼SUV值在不同性别间无统计学差异(P > 0.05)。脊柱及骨盆的SUVmax和SUVmean与身高均无显著相关性(P值均>0.05),与年龄普遍呈负相关性,与体重及CT值普遍呈正相关关系。结论:骨定量xSPECT/CT可获得99mTc-MDP在正常骨骼中的SUV值,可用于骨转移诊断及评估的参考;不同部位骨骼SUV值存在一定差异,应用SUV值诊断和评估肿瘤骨转移时需具体部位具体分析。 |
关键词: 单光子发射计算机体层成像/计算机体层成像 标准化摄取值 锝[[sub_s][sup_s]99m[sup_e][sub_e]Tc]-亚甲基二磷酸盐 |
DOI:10.12025/j.issn.1008-6358.2020.20201065 |
分类号: |
基金项目:上海市临床重点专科项目(shslczdzk03401),西门子公司资助项目《骨定量SPECT/CT显像用于乳腺癌与前列腺癌骨转移疗效评价的临床应用研究》(H2019-101) |
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The normal distribution characteristics of standardized uptake value of spine and pelvis with 99mTc-MDP quantitative SPECT / CT in Chinese people |
HOUXIAOGUANG, LIUGUOBING, LIUSIWEI, SUNDENGQIN, YUHAOJUN, GUYUSHEN
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Zhongshan Hospital,Fudan University
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Abstract: |
Objective: To study the normal distribution characteristics of standardized uptake value (SUV) of spine and pelvis with 99mTc-methylene diphosphate (99mTc-MDP) in Chinese people Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) imaging. Methods: This retrospective study was performed on 500 enrolled patients with cancer undergoing bone quantitative xSPECT/CT with 99mTc-MDP. The maximum and mean SUV (SUVmax and SUVmean) of were measured. Furthermore, the distribution of SUV in normal bone and its correlation with age, height, weight and the CT value was assessed. Results: The maximum?SUVmax and SUVmean were in the sixth cervical vertebra (7.4 ± 2.4 and 6.0 ± 2.1 respectively), and the minimum in the third sacral vertebra (4.4 ± 2.0 and 2.2 ± 1.1 respectively). The coefficient of variation (CV) of SUVmax and SUVmean in spine and pelvis were similar, ranging from 31.6% to 45.6% and 34.1% to 52.7% respectively. The variation between individuals of SUVmax(CVpelvis = 42.4%, CVspine= 35.0%)and SUVmean (CVpelvis = 52.7% , CVspine = 38.3%) in pelvis were slightly larger than that of spine. There was no significant difference (P>0.05) between male and female. There was no significant correlation between SUVmax and SUVmean of spine and pelvis and height (P > 0.05). In addition, both SUVmax and SUVmean showed negative correlation with age, and positive correlation with weight and CT values. Conclusion: The SUV of 99mTc-MDP in normal bone can be obtained by bone quantitative xSPECT/CT, which can reflect the mineral metabolism of bone and be used as a reference for the diagnosis and evaluation of bone metastasis. There are some differences in the SUV of different parts of bone. The application of SUV in diagnosing and evaluating bone metastasis should be region specified. |
Key words: : single photon emission computed tomography computed tomography standardized uptake value 99mTc- methylene diphosphate |