摘要: |
目的:探讨立体定向放疗(stereotactic body radiotherapy,SBRT)对不可手术切除的肝转移癌患者的临床疗效。方法:回顾性分析2018年3月至2019年11月同济大学附属东方医院收治的28例肝转移癌患者的临床资料。予4D-CT或呼吸门控技术进行CT模拟定位,予肝转移病灶50Gy/10f的剂量分割模式。结果:所有患者均顺利完成全程放疗。半年和1年的总生存率(overall survival,OS)为95.0%和70.1%。1年的局部控制率(local control,LC)为92.2%。常见的不良反应为Ⅰ~Ⅱ级的恶心、纳差、腹痛等,无Ⅲ级以上的不良反应发生。结论:以50Gy/10f分割模式的立体定向放射治疗技术治疗肝转移癌安全有效。 |
关键词: 肝转移癌 立体定向放疗 结直肠癌 |
DOI:10.12025/j.issn.1008-6358.2020.20200254 |
分类号:R735.7 |
基金项目:国家自然科学基金(81960525),上海市科技创新项目(19DZ1930903),上海自然科学基金(17zr1405300),上海科技支撑项目(17411962600),上海市浦东新区科技和经济委员会民生项目(PKJ2018-Y02),江西省自然科学基金(20192BAB205071). |
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Stereotactic body radiotherapy with 50 Gy in 10 fractions for unresectable liver metastasis |
LU Zhen-guo, SUN Jun-die, XIANG Zuo-lin, LU Xin, WANG Ai-hua, YUAN Jun
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Department of Radiation Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
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Abstract: |
Objective:To explore the clinical efficacy of stereotactic body radiotherapy (SBRT) for the treatment of patients with unresectable liver metastasis. Methods:Data of 28 patients with unresectable liver metastases were retrospectively analyzed. All patients were admitted to the Shanghai East Hospital from March 2018 to November 2019. Patients underwent 4D-CT or respiration gating for CT simulation. The prescription dose for the liver metastasis was 50 Gy in 10 fractions. Results:All patients successfully completed the SBRT treatment. The median overall survival was 7.4 months. The six months and one-year survival rates were 95.0% and 70.1%, respectively. The local control rate for one year was 92.2%. The most common toxicity was grade Ⅰ or Ⅱ nausea, poor appetite, and abdominal pain. No grade Ⅲ or worse toxicity was found. Conclusions:SBRT with 50 Gy in 10 fractions is a safe and effective treatment for patients with unresectable liver metastasis. |
Key words: liver metastasis stereotactic body radiotherapy (SBRT) colorectal cancer |