摘要: |
α-crystallins是小分子热休克蛋白家族(small-molecule heat shock protein,sHSP)的重要成员,包括αA-crystallin和αB-crystallin,在各类组织细胞中具有细胞保护和分子伴侣功能。近年来,多项研究发现,视网膜组织α-crystallins可利用自身特性通过各种途径参与增生性视网膜病的血管新生、上皮/内皮细胞间质化等过程。本文主要介绍α-crystallins,尤其是αB-crystallin调节增生性视网膜疾病发展的分子机制,探讨其潜在的临床应用价值。 |
关键词: α-crystallins 糖尿病视网膜病 黄斑变性 玻璃体视网膜病变 血管生成 上皮间质化转变 |
DOI:10.12025/j.issn.1008-6358.2020.20191952 |
分类号:R774.1 |
基金项目:国家自然科学基金(81970817,81873680). |
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Research progress of retinal α-crystallins in proliferative retinal diseases |
XU Ya-hui, YUAN Yuan-zhi
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Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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Abstract: |
α-crystallins are an important member of the small-molecule heat shock protein family (sHSP), including αA-crystallin and αB-crystallin, which have cytoprotection and molecular chaperone functions in various cells and tissues. In recent years, it has been found that retinal α-crystallins are involved in proliferative retinal diseases via regulating angiogenesis and epithelial/endothelial-mesenchymal transition. This article introduces the specific mechanism of α-crystallins, especially αB-crystallin, in regulating the development of proliferative retinal diseases, and its potential clinical application. |
Key words: α-crystallins diabetic retinopathy macular degeneration vitreoretinopathy angiogenesis epithelial-mesenchymal transition |