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巨噬细胞在心肌梗死中作用的研究进展 |
董正1,2, 吴润达1,2, 孙爱军1,2, 葛均波1,2
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1.复旦大学附属中山医院心内科, 上海 200032;2.上海市心血管病研究所, 上海 200032
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摘要: |
心肌梗死导致心肌细胞缺血坏死并引发严重的炎症反应,此时大量的巨噬细胞被募集至心脏以清除死亡心肌组织,同时分泌多种细胞因子和趋化因子,协助吞噬坏死细胞碎片并促进组织修复。这个过程由多种因素调控,并主要与组织微环境相关。但在一些情况下,巨噬细胞调控失衡会造成不可逆的损伤,并加速心力衰竭的过程。本篇综述主要梳理了心脏中巨噬细胞的类型,并探讨巨噬细胞在发生心肌梗死后发挥作用的过程。 |
关键词: 巨噬细胞 心肌梗死 炎症反应 |
DOI:10.12025/j.issn.1008-6358.2020.20192282 |
分类号:R714.252 |
基金项目:国家自然科学基金(81521001,81570224,81725002,91639104). |
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Progress of role of macrophage in myocardial infarction |
DONG Zheng1,2, WU Run-da1,2, SUN Ai-jun1,2, GE Jun-bo1,2
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1.Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China;2.Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China
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Abstract: |
Myocardial infarction leads to myocardial apoptosis and causes severe inflammation response. Tons of macrophages are recruited to the heart removing dying tissue, and many cytokines and chemokine are secreted to help scavenge cell debris and promote healing. This process is regulated by many factors and is mainly related to the local microenvironment. But under some circumstances, the imbalance of macrophage regulation can cause irreversible damage and accelerate the process of heart failure. This view reviews the types of macrophages in the heart and discusses the role of macrophages after myocardial infarction. |
Key words: macrophages myocardial infarction inflammation response |