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丙肝相关性肝癌切除术后的预后因素分析 |
於雷1, 王征1, 代智1, 樊嘉1,2,3, 周俭1,2,3
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1.复旦大学附属中山医院肝肿瘤外科, 上海 200032;2.复旦大学肝癌研究所, 上海 200032;3.癌变与侵袭原理教育部重点实验室, 上海 200032
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摘要: |
目的:评估各项临床指标及中国肝癌分期(CNLC)在丙肝相关性肝癌中的预后价值。方法:共招募126例在复旦大学附属中山医院肝外科行肝癌切除术的丙肝相关性肝癌患者,结合术后随访信息,分析各项临床指标与预后的关系。结果:Kaplan-Meier生存曲线分析结果表明:术前甲胎蛋白(AFP)、术前白蛋白(ALB)、最大肿瘤直径、肿瘤包膜、血管侵犯及CNLC分期与肝癌术后总体生存率显著相关。利用Cox模型行多因素回归分析提示:术前AFP、术前白蛋白、最大肿瘤直径、血管侵犯及CNLC分期是肝癌患者总体生存的独立预后因素。结论:本研究明确了我国丙肝相关性肝癌患者临床指标与预后的关系,并验证了CNLC在此部分患者中的预后价值。 |
关键词: 丙肝 肝癌 预后 中国肝癌分期 |
DOI:10.12025/j.issn.1008-6358.2020.20201705 |
分类号:R735.7 |
基金项目:国家重点研发计划(2019YFC1315800),国家自然科学基金青年基金项目(81301821). |
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Prognostic factors of hepatitis C-related hepatocellular carcinoma after curative resection |
YU Lei1, WANG Zheng1, DAI Zhi1, FAN Jia1,2,3, ZHOU Jian1,2,3
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1.Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China;2.Liver Cancer Institute, Fudan University, Shanghai 200032, China;3.Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China
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Abstract: |
Objective: To evaluate the prognostic value of clinical characteristics including China Liver Cancer staging system (CNLC) for patients with hepatitis C-related hepatocellular carcinoma after curative resection. Methods: A total of 126 HCC patients with hepatitis C who underwent a curative hepatic resection in Zhongshan Hospital were enrolled in this study. Major clinical parameters and surgical outcomes were analyzed for long-term survival. Results: Kaplan-Meier curve was applied to evaluate the relationship between clinical characteristics and prognosis. Pre-operative AFP and albumin level, maximum tumor diameter, tumor encapsulation, vascular invasion, and CNLC stage were significantly associated with overall survival. Cox regression model indicated elevated AFP level and decreased albumin level, maximum tumor diameter, tumor encapsulation, vascular invasion, and CNLC stage were significant poor prognostic factors for post-operative overall survival. Conclusions: This research indicates the relationship between clinical indicators and prognosis of patients with hepatitis C-related HCC, and verify the prognostic value of CNLC staging in these patients. |
Key words: hepatitis C hepatocellular carcinoma prognosis China liver cancer staging |