摘要: |
前列腺素E2主要由颗粒细胞合成,是大多数哺乳类动物排卵卵泡中关键的调节分子。排卵过程中,黄体生成激素激增,通过环氧合酶-2和前列腺素合酶诱导颗粒细胞合成前列腺素E2。前列腺素E2释放到胞外后,通过结合卵丘颗粒细胞上前列腺素E2受体2和受体4,诱导丝裂原活化蛋白激酶磷酸化,增加胞内环磷酸腺苷水平,并激活蛋白激酶B和丝裂原活化蛋白激酶通路,促进排卵发生。前列腺素E2的调控异常与多种排卵障碍性疾病有关,如多囊卵巢综合征和未破裂卵泡黄素化综合征等。 |
关键词: 前列腺素 卵泡 排卵 卵丘细胞 |
DOI:10.12025/j.issn.1008-6358.2020.20191032 |
分类号:R321.1 |
基金项目:第二军医大学临床遗传学本科生实验平台建设(PT2017009),海军军医大学教育改革课题面上项目(JYC2017005). |
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Research progress on the role of prostaglandin E2 in ovulation and its mechanism |
DONG Jun-peng, YANG Fu
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Department of Medical Genetics, Naval Millitary Medical University, Shanghai 200433, China
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Abstract: |
Prostaglandin E2 (PGE2) is mainly synthesized by granulosa cells and is a key intrafollicular mediator of ovulation in many mammalian species. In ovulation process, luteinizing hormone (LH) sharply increases and induces granulosa cells to synthesize PGE2 via cyclooxygenase-2 (COX-2) and prostaglandin E synthase (PGES). After released to extracellular space, PGE2 combines to the receptor 2 (PTGER2) and PTGER4 on cumulus cells and induces mitogen activated protein kinase (MAPK) phosphorylation, increases the intracellular cAMP level and activates the protein kinase B (PKB) and MAPK pathway, so as to promote the occurrence of ovulation. The abnormal regulation of PGE2 is associated with a variety of ovulatory disorders, such as polycystic ovary syndrome (PCOS) and luteinized unruptured follicle syndrome (LUFS). |
Key words: prostaglandin follicles ovulation cumulus cells |