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肝癌患者肝移植术前使用PD-1抑制剂对移植后排斥反应的影响 |
崔春晓1, 杨柳晓1, 王颖1, 黄俊峰1, 黄晓武2, 樊嘉2, 周俭2, 王婷1
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1.复旦大学附属中山医院肝移植重症监护室, 上海 200032;2.复旦大学附属中山医院(肝癌研究所)肝外科, 上海 200032
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摘要: |
目的: 观察肝癌患者肝移植术前使用PD-1抑制剂对肝移植术后排斥反应的影响。方法: 选取2019年1月1日至2019年12月31日在复旦大学附属中山医院行肝移植且移植前接受过PD-1抑制剂治疗的肝癌患者,共12例。检测其术后早期他克莫司药物浓度,观察移植术后排斥反应发生情况。结果: 术后第1周和第2周他克莫司浓度分别为(5.14±2.68)ng/mL和(8.41±5.73)ng/mL。16.7%(2/12)患者发生细胞性排斥。结论: 肝移植术前使用PD-1抑制剂的肝癌患者,其移植术后排斥反应的发生率未见明显增加。 |
关键词: 肝移植 PD-1抑制剂 排斥 肝癌 |
DOI:10.12025/j.issn.1008-6358.2020.20201005 |
分类号:R735.7 |
基金项目:国家自然科学基金(81972232). |
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The effect of PD-1 inhibitor treatment before liver transplantation on posttransplant rejection in liver cancer patients |
CUI Chun-xiao1, YANG Liu-xiao1, WANG Ying1, HUANG Jun-feng1, HUANG Xiao-wu2, FAN Jia2, ZHOU Jian2, WANG Ting1
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1.Liver Transplantation Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai 200032, China;2.Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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Abstract: |
Objective: To observe the effect of PD-1 inhibitor treatment before liver transplantation on posttransplant rejection in liver cancer patients.Methods: The data of 12 patients with liver cancer who received PD-1 inhibitor before liver transplantation between January 1 and December 31, 2019 in Zhongshan Hospital, Fudan University were analyzed. The concentration of tacrolimus in the early postoperative period were detected and the occurrence of rejection after transplantation were observed.Results: The tacroliums concentration at 1week or 2 week after liver transplantation were (5.14±2.68) ng/mL and (8.41±5.73) ng/mL. The incidence of rejection after liver transplantation was only 16.7%(2/12).Conclusions: The incidence of rejection after liver transplantation is not significantly increased in patients with liver cancer who use PD-1 inhibitors before liver transplantation. |
Key words: liver transplantation PD-1 inhibitor rejection liver cancer |