摘要: |
负压创面疗法治疗铜绿假单胞菌感染创面的有效性已在临床上得到验证,但其作用机制尚未完全明确。对其作用机制的深入理解,不但有助于改进其设计和功能,也有助于进一步提高临床治疗效果。因此,本文就近年来负压创面疗法治疗铜绿假单胞菌感染创面作用机制的最新研究进展作一综述,具体包括:细菌数量变化、生物膜结构改变、细菌毒力减弱、炎症反应调控等机制以及辅助其他抗菌治疗方法提升杀菌效果等。 |
关键词: 负压创面疗法 铜绿假单胞菌 生物膜 |
DOI:10.12025/j.issn.1008-6358.2019.20190653 |
分类号: |
基金项目:北京市自然科学基金(7172211),北京市科委临床特色应用研究项目(Z161100000516179). |
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Research progress in negative pressure wound therapy for the treatment of Pseudomonas aeruginosa infection |
YU Qing-wen1,2, LUO Xiao-bo1, LIU Dao-hong1
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1.Department of Orthopedics, 8th Medical Center of General Hospital of PLA, Beijing 100091, China;2.Department of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China
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Abstract: |
The efficacy of negative pressure wound therapy in treating Pseudomonas aeruginosa infected wounds has been clinically verified, however, its mechanism of action has not yet been fully clarified.. Further understanding of its mechanism of action can not only help to improve its design and function, but also help to further improve the clinical treatment effect. This article reviews recent advances in the study of negative pressure wound therapy in the treatment of P. aeruginosa infections. The widely accepted mechanisms include reducing the number of P. aeruginosa, altering biofilm structure, affecting virulence, and inhibiting inflammatory responses, as well as assisting other antibacterial treatment methods to improve the sterilization effect, etc. |
Key words: negative pressure wound therapy pseudomonas aeruginosa biofilm |