摘要: |
目的:探讨常规超声心动图对蒽环类化疗药物所致心脏毒性的诊断价值。方法:选取2014年2月至2017年6月在我院接受蒽环类药物化疗的乳腺癌术后患者136例,给予吡柔比星+环磷酰胺+多西他赛方案化疗6个周期。疗程结束后,根据患者是否发生心脏毒性分为心脏毒性组(N=48)和无心脏毒性组(N=76),对比患者化疗前后的超声心动图参数,分析常规超声心动图参数在早期心脏毒性诊断中的价值。结果:心脏毒性组TAPSE、E/A和E/a,值显著低于无心脏毒性组(P<0.05)。ROC曲线分析,TAPSE、E/A和E/e'对应的曲线下面积分别为0.917(0.874,0.962)、0.902(0.853,0.957)、0.845(0.823,0.921)。TAPSE的截断值为20.78 mm、E/A的截断值为1.19、E/e'的截断值为8.59,Youden指数分别为0.842、0.761、0.712。结论:常规超声心动图在蒽环类药物心脏毒性诊断中具有一定价值。 |
关键词: 常规超声心动图 蒽环类化疗药物 心脏毒性 |
DOI:10.12025/j.issn.1008-6358.2019.20181074 |
分类号:R445.1 |
基金项目: |
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Diagnostic value of conventional echocardiographic for cardiotoxicity caused by anthracycline chemotherapy drugs |
LI Ji1, GUO Hai-jian2
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1.Department of Ultrasound, Rugao People's Hospital, Jiangsu Province, Rugao 226500, Jiangsu, China;2.Echo Room, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China
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Abstract: |
Objective: To investigate the diagnostic value of conventional echocardiography for cardiotoxicity caused by anthracycline chemotherapy drugs. Methods: A total of 136 postoperative patients with breast cancer who underwent anthracycline chemotherapy in our hospital from February 2014 to June 2017 were enrolled. Six cycles of pirarubicin+cyclophosphamide+docetaxel chemotherapy were given. At the end of the treatment, patients were divided into cardiotoxicity group (N=48) and no cardiotoxicity group (N=76). The echocardiographic parameters of the patients before and after chemotherapy were compared, and the value of the conventional echocardiographic parameters was analyzed in the early diagnosis of cardiotoxicity. Results: The values of TAPSE, E/A, and E/a in the cardiotoxic group were significantly lower than those in the no cardiotoxicity group (P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the corresponding ROC curve of TAPSE, E/A, and E/e' were 0.917 (0.874, 0.962), 0.902 (0.853, 0.957), and 0.845 (0.823, 0.921), respectively. The cutoff value of TAPSE, E/A, and E/e' were 20.78, 1.19, and 8.59 mm, and the Youden index is 0.842, 0.761, and 0.712, respectively. Conclusions: Conventional echocardiography has certain value in the diagnosis of cardiotoxicity caused by anthracyclines. |
Key words: conventional echocardiography anthracycline chemotherapy cardiotoxicity |