摘要: |
目的:探讨慢性阻塞性肺疾病(COPD)患者夜间低氧与全身炎症反应的关系。方法:选择中度至极重度COPD患者70例,年龄45~74岁,平均(65.41±7.84)岁。按多导睡眠监测结果将研究对象分为低氧组和非低氧组,均行肺功能和多导睡眠监测、炎症指标检测。比较各组血清IL-6及IL-8的差异,分析炎症指标与睡眠呼吸参数的相关性。结果:睡眠低氧组27例,低氧率为38.57%,低氧组血清IL-6、IL-8分别为(14.34±2.76)ng/mL、(68.49±9.65)ng/mL,明显高于非低氧组的(11.79±1.85)ng/mL、(61.62±8.47)ng/mL(均P<0.001)。经校正年龄、体质量指数后,IL-6与睡眠呼吸相关参数TS88正相关(r=0.651,P=0.041),与最低SaO2和平均SaO2负相关(r=-0.644,P=0.038和r=-0.780,P=0.018);IL-8与睡眠呼吸相关参数TS88正相关(r=0.627,P=0.039),与最低SaO2和平均SaO2负相关(r=-0.659,P=0.026和r=-0.732,P=0.014)。结论:中度至极重度COPD患者夜间低氧普遍存在,低氧组患者全身炎症反应明显增强,全身炎症反应与夜间低氧相关。 |
关键词: 慢性阻塞性肺疾病 夜间低氧 多导睡眠监测 白细胞介素-6 白细胞介素-8 |
DOI:10.12025/j.issn.1008-6358.2019.20191464 |
分类号:R563.1 |
基金项目:苏州市相城科技发展基金(xj201642). |
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Effects of nocturnal hypoxia on serum IL-6 and IL-8 in patients with chronic obstructive pulmonary disease |
WANG Yong-bin, TANG Ying, ZHANG Xiao-lan, ZHANG Yi-hong
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Department of Respiration, Suzhou Xiangcheng People's Hospital, Suzhou 215131, Jiangsu, China
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Abstract: |
Objective: To investigate the association between nocturnal hypoxia and systemic inflammatory response in patients with chronic obstructive pulmonary disease.Methods: Seventy moderate to very severe stable COPD patients with an age range of 45-74 years (Average age,[65.41±7.84] years) were included.Patients were divided into nocturnal hypoxia group and non-nocturnal hypoxia group, and lung function, PSG, and inflammatory indicators were performed. The differences of serum IL-6 and IL-8 in each group were compared, the correlation between IL-6 and IL-8 as well as PSG parameters were further evaluated using partial correlation analysis.Results: Twenty-seven patients (38.57%) with nocturnal hypoxia were enrolled.Compared with patients without nocturnal hypoxia, serum IL-6 and IL-8 in the hypoxic group ([14.34±2.76] ng/mL and[68.49±9.65] ng/mL, respectively) were significantly higher than those in the non-nocturnal hypoxic group ([11.79±1.85] ng/mL and[61.62±8.47] ng/mL, respectively; P<0.001). Additionally, after adjustment for BMI and age, serum IL-6 level showed significant positive correlation with TS88 (r=0.651, P=0.041), nevertheless, serum IL-6 level showed significant negative correlation with the lowest SaO2 and the mean SaO2 (r=-0.644, P=0.038 and r=-0.780, P=0.018); serum IL-8 level showed significant positive correlations with TS88 (r=0.627, P=0.039), nevertheless, serum IL-6 level showed significant negative correlation with the lowest SaO2 and the mean SaO2 (r=-0.659,P=0.026 and r=-0.732, P=0.014).Conclusions: Nocturnal hypoxia generally exists in patients with moderate to very severe stable COPD. Compared with the non-nocturnal hypoxia group, the nocturnal hypoxia group has enhanced systemic inflammatory response, which might be correlated with nocturnal hypoxia. |
Key words: chronic obstructive pulmonary disease nocturnal hypoxia polysomnography interleukin-6 interleukin-8 |